{
  "abstract": "Regular physical activity improves physical capacity and overall health by enhancing cardiopulmonary function and muscle strength, reducing stress, and improving psychological well‑being and quality of life. Despite these known benefits, the molecular mechanisms that underlie these effects remain incompletely understood. Lactylation, a modification wherein lactate molecules form ester bonds with proteins, induces functional changes in these proteins. Evidence indicates that exercise can regulate lactylation, which, in turn, affects intracellular signaling pathways and metabolic processes. This modulation plays a role in promoting health and facilitating disease alleviation. The present review offers an extensive review of the mechanisms through which exercise influences lactylation and discusses the potential clinical applications of lactylation in the prevention and treatment of exercise‑related diseases.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physical Education and Safety, Xinjiang Vocational University, Urumqi, Xinjiang Uyghur Autonomous Region 830039, P.R. China.",
    "Department of Rehabilitation, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jinlin 130117, P.R. China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jian Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Lei Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0nfy570cdzhj8.bib",
  "cited_by": 0,
  "doi": "10.3892/mmr.2026.14035",
  "fulltext_url": "https://europepmc.org/articles/PMC13659189",
  "id": "0nfy570cdzhj8",
  "issns": [
    "1791-2997",
    "1791-3004"
  ],
  "landing_url": "https://europepmc.org/article/MED/42852621",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Exercise and Physiological Responses"
    ]
  ],
  "openalex": "W7216040408",
  "pdf_url": "https://europepmc.org/articles/PMC13659189?pdf=render",
  "pmcid": "PMC13659189",
  "pmid": "42852621",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0nfy570cdzhj8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42852621",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42852621"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Exercise and Physiological Responses",
      "subfield": "general"
    }
  ],
  "title": "Lactylation and exercise: A molecular link to disease alleviation (Review).",
  "title_text": "Lactylation and exercise: A molecular link to disease alleviation (Review).",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/0nfy570cdzhj8",
  "venue": "Molecular medicine reports",
  "versions": []
}