{
  "abstract": "Purpose\n\nBoron neutron capture therapy (BNCT) was approved in Japan in June 2020 as a curative option for unresectable, locally advanced, or recurrent head and neck cancers. Relevantly, its efficacy and safety in clinical practice should be regularly monitored, particularly regarding its optimal positioning. Therefore, to advance its clinical application, we assessed clinical data on BNCT for head and neck cancers.Methods\n\nWe retrospectively analyzed 285 patients who received initial BNCT between June 2020 and May 2024 with available ≥1 month follow-up data. The primary endpoint was local control (LC); secondary endpoints included progression-free survival (PFS), overall survival (OS), treatment response, and grade ≥ 3 adverse events.Results\n\nThe 2-year LC, PFS, and OS rates were 41.5%, 26.4%, and 59.2%, respectively. The complete response (CR), partial response (PR), and objective response (CR + PR) rates were 47.0%, 33.3%, and 80.4%, respectively. The cumulative incidence of grade ≥ 3 late adverse events was 14.0% at 2 years, with grade 5 adverse events occurring in 2.1% of patients. No significant differences were observed in LC or PFS among histological type subgroups; however, OS was significantly worse in patients with squamous cell carcinoma (SqCC) than in patients with non-SqCC. Regarding TNM stage at irradiation, radiation therapy at an early disease stage was significantly associated with improved LC.Conclusions\n\nBNCT should be administered during the early disease stages when no other effective treatment options are available. Further studies should determine the factors contributing to treatment efficacy and safety, thereby optimizing multimodal treatment strategies involving BNCT.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.",
    "Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.",
    "Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.",
    "Department of Otorhinolaryngology - Head and Neck Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.",
    "Department of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.",
    "Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.",
    "BNCT Joint Clinical Institute, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Satoshi Takeno"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yuki Yoshino"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Teruhito Aihara"
    },
    {
      "affs": [
        3
      ],
      "name": "Takaki Inui"
    },
    {
      "affs": [
        3
      ],
      "name": "Tsuyoshi Jinnin"
    },
    {
      "affs": [
        3
      ],
      "name": "Ichita Kinoshita"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Kazuma Kobata"
    },
    {
      "affs": [
        0
      ],
      "name": "Mari Mukai"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "Naonori Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Akinori Sasaki"
    },
    {
      "affs": [
        1
      ],
      "name": "Mai Nojiri"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Yasukazu Kanai"
    },
    {
      "affs": [
        3
      ],
      "name": "Tetsuya Terada"
    },
    {
      "affs": [
        3
      ],
      "name": "Shin-Ichi Haginomori"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Keiji Nihei"
    },
    {
      "affs": [
        6
      ],
      "name": "Koji Ono"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0nn3jmxncp9by.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ctro.2026.101316",
  "fulltext_url": "https://europepmc.org/articles/PMC13677289",
  "id": "0nn3jmxncp9by",
  "issns": [
    "2405-6308"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898130",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Boron Compounds in Chemistry"
    ]
  ],
  "openalex": "W7220921267",
  "pdf_url": "https://europepmc.org/articles/PMC13677289?pdf=render",
  "pmcid": "PMC13677289",
  "pmid": "42898130",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0nn3jmxncp9by.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898130",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898130"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Boron Compounds in Chemistry",
      "subfield": "imaging"
    }
  ],
  "title": "Current role of boron neutron capture therapy in head and neck cancer: insights from 4 years of clinical experience.",
  "title_text": "Current role of boron neutron capture therapy in head and neck cancer: insights from 4 years of clinical experience.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/0nn3jmxncp9by",
  "venue": "Clinical and translational radiation oncology",
  "versions": []
}