{
  "abstract": "Background: Guideline-directed medical therapy (GDMT) reduces mortality and rehospitalization in heart failure with reduced ejection fraction (HFrEF), yet many hospitalized patients are discharged without optimal therapy.\n\nProject Rationale: A baseline audit at our community teaching hospital showed fewer than half of eligible patients were discharged on ≥3 GDMT pillars, driven by cost barriers, deferred titration, and inconsistent education.\n\nProject Summary: A multidisciplinary Plan-Do-Study-Act intervention standardized GDMT workflows, incorporating pharmacist-led admission review, structured checklists, teach-back counseling, a meds-to-beds program, and early outpatient follow-up. Among 62 postintervention versus 152 baseline patients, discharge on ≥3 pillars increased from 47.4% to 69.4% (P = 0.006), heart failure–specific 30-day readmissions decreased from 23.7% to 9.7% (P = 0.022), and all-cause readmissions from 30.9% to 16.1% (P = 0.028).\n\nLimitations: Modest postintervention sample size warrants cautious interpretation.\n\nTake-Home Message: Structured, pharmacy-supported GDMT workflows improved prescribing performance and reduced 30-day readmissions in HFrEF.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Landmark Medical Center, Woonsocket, Rhode Island, USA",
    "Department of Pharmacy, Landmark Medical Center, Woonsocket, Rhode Island, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Abdul Allam Khan"
    },
    {
      "affs": [
        1
      ],
      "name": "Matthew Amaral"
    },
    {
      "affs": [
        0
      ],
      "name": "Manav Ghaie"
    },
    {
      "affs": [
        0
      ],
      "name": "Huzaifa Rashid"
    },
    {
      "affs": [
        0
      ],
      "name": "Jenna Iannuccilli"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ntr87phym5za.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jaccas.2026.109658",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13728395/",
  "id": "0ntr87phym5za",
  "issns": [
    "2666-0849"
  ],
  "landing_url": "https://doi.org/10.1016/j.jaccas.2026.109658",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Outcomes and Quality"
    ],
    [
      "heading",
      "Quality Improvement Projects"
    ],
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7213428938",
  "pdf_url": null,
  "pmcid": "PMC13728395",
  "pmid": "42752014",
  "published": "2026-09-16",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0ntr87phym5za.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:21:23Z",
      "native_id": "PMC13728395",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jaccas.2026.109658"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Improving Guideline-Directed Medical Therapy in Hospitalized HFrEF Patients",
  "title_text": "Improving Guideline-Directed Medical Therapy in Hospitalized HFrEF Patients",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:23Z",
  "url": "https://research.draconitic.com/paper/0ntr87phym5za",
  "venue": "JACC Case Reports",
  "versions": []
}