{
  "abstract": "ADP-ribosylation is a posttranslational modification conserved across all domains of life and some viruses. While it is well established as a critical signalling mechanism in humans and is widely exploited as a therapeutic target in cancer, its roles in other kingdoms, particularly Fungi, remain poorly understood. Despite this, recent advances highlight the importance of fungal ADP-ribosylation in the regulation of key cellular maintenance processes such as DNA damage and oxidative stress responses, morphogenesis, growth, and proliferation. Here, we summarise our current understanding of fungal ADP-ribosylation and how it supports stress adaptation and virulence. While many aspects of fungal ADP-ribosylation remain unexplored, emerging discoveries underscore its importance in fungal biology and hint at a great potential for future antifungal therapies.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Research Council Centre for Medical Mycology, University of Exeter, Department of Bioscience, Faculty of Health and Life Sciences, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, U.K."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Johanna Mary Martha Gosciniak"
    },
    {
      "affs": [
        0
      ],
      "name": "Johannes Gregor Matthias Rack",
      "orcid": "0000-0001-8341-6439"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0p0vpnvhkhns7.bib",
  "cited_by": 0,
  "doi": "10.1042/bst20260689",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720257/",
  "id": "0p0vpnvhkhns7",
  "issns": [
    "0300-5127",
    "1470-8752"
  ],
  "landing_url": "https://doi.org/10.1042/bst20260689",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Host-Microbe Interactions"
    ],
    [
      "heading",
      "Microbiology"
    ],
    [
      "heading",
      "Molecular Bases of Health & Disease"
    ],
    [
      "heading",
      "Review Articles"
    ],
    [
      "heading",
      "Signaling"
    ],
    [
      "openalex",
      "1312|Fungal and yeast genetics research"
    ]
  ],
  "openalex": "W7224666142",
  "pdf_url": "https://portlandpress.com/biochemsoctrans/article-pdf/54/11/1569/993426/bst-2026-0689c.pdf",
  "pmcid": "PMC13720257",
  "pmid": "42952472",
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0p0vpnvhkhns7.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:11Z",
      "native_id": "PMC13720257",
      "source": "pmc",
      "url": "https://doi.org/10.1042/bst20260689"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Fungal ADP-ribosylation: an emerging signalling pathway in adaptation and virulence",
  "title_text": "Fungal ADP-ribosylation: an emerging signalling pathway in adaptation and virulence",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:11Z",
  "url": "https://research.draconitic.com/paper/0p0vpnvhkhns7",
  "venue": "Biochemical Society Transactions",
  "versions": []
}