{
  "abstract": "Background\n\nNeoadjuvant chemotherapy is recommended as the standard of care for eligible patients with locally advanced resectable gastric adenocarcinoma. However, given the often-late diagnosis of this tumor, understanding post-neoadjuvant therapy lymph node involvement remains a determining factor in the prognosis of these patients.Aims\n\nTo evaluate the association between reduced tumor staging after neoadjuvant therapy and lymph node involvement in patients with gastric adenocarcinoma.Methods\n\nThis is a retrospective, analytical, observational study based on the medical records of patients who underwent combination therapy from 2018 to 2024. Pre-treatment clinical staging was performed according to institutional protocol, and the relationship between tumor and lymph node staging was established by comparing the initial clinical staging with the post-treatment pathological staging.Results\n\nEighty-nine patients were included in the analysis, with a reduction in tumor staging observed in 47.2% of cases, based on pathological T-cell analysis. The mean number of affected lymph nodes was significantly higher in non-responder patients compared to responders (5.0±6.3 versus 1.1±2.2; p<0.001). Simple logistic regression analysis identified that the number of affected lymph nodes was associated with the absence of tumor response in univariate analysis, presenting an odds ratio of 1.317 (95%CI 1.099-1.579; p=0.003).Conclusions\n\nThe absence of reduction in tumor staging was associated with a higher residual lymph node burden, highlighting the prognostic relevance of lymph node involvement in post-therapeutic evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade Federal do Pará, General and Digestive Surgery Service - Belém (PA), Brazil.",
    "Universidade do Estado do Pará, Center for Biological and Health Sciences - Belém (PA), Brazil.",
    "Universidade Federal do Pará, Medical Oncology Service - Belém (PA), Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Geraldo Ishak",
      "orcid": "0009-0000-8299-2514"
    },
    {
      "affs": [
        0
      ],
      "name": "Luciana Roberta do Vale Corrêa",
      "orcid": "0000-0001-8300-5250"
    },
    {
      "affs": [
        0
      ],
      "name": "Thaygo de Azevedo Neves",
      "orcid": "0009-0007-3667-8453"
    },
    {
      "affs": [
        1
      ],
      "name": "Ricardo Ormanes Massoud",
      "orcid": "0000-0002-1140-8584"
    },
    {
      "affs": [
        0
      ],
      "name": "Ives Uchôa de Azevedo",
      "orcid": "0009-0002-2942-1936"
    },
    {
      "affs": [
        0
      ],
      "name": "Pedro Antônio Mufarrej Hage",
      "orcid": "0009-0003-3103-975X"
    },
    {
      "affs": [
        2
      ],
      "name": "Williams Fernandes Barra",
      "orcid": "0000-0001-8954-4212"
    },
    {
      "affs": [
        0
      ],
      "name": "Paulo Pimentel de Assumpção",
      "orcid": "0000-0003-3846-8445"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0p4e03vqz3zjf.bib",
  "cited_by": 0,
  "doi": "10.1590/0102-672020260000049e1978",
  "fulltext_url": "https://europepmc.org/articles/PMC13652512",
  "id": "0p4e03vqz3zjf",
  "issns": [
    "0102-6720",
    "2317-6326"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912028",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Gastric Cancer Management and Outcomes"
    ]
  ],
  "openalex": "W7214598086",
  "pdf_url": "https://europepmc.org/articles/PMC13652512?pdf=render",
  "pmcid": "PMC13652512",
  "pmid": "42912028",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0p4e03vqz3zjf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42912028",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912028"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2746|Bariatric Surgery and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Post-neoadjuvant therapy lymph node response in patients with gastric adenocarcinoma.",
  "title_text": "Post-neoadjuvant therapy lymph node response in patients with gastric adenocarcinoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/0p4e03vqz3zjf",
  "venue": "Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery",
  "versions": []
}