{
  "abstract": "Background\n\nA short single low-humidity stay (SSLHS) induces rapid changes in stratum corneum (SC) function, but their significance and inter-individual variability remain unclear. We examined associations between baseline SC function and rapid SSLHS responses and evaluated whether a lotion-free fine fiber (FF) film modulates these responses.Materials and methods\n\nForty healthy Japanese women (n = 40) completed 6-h stays at 60% RH and, on the next day, 20% RH (23°C). TEWL, capacitance, and skin texture were measured on the open cheek at 0, 3, and 6 h. During SSLHS, an FF film was applied to the right half of the face and assessed at 0 and 6 h. Pearson's r and within-subject differences in absolute change (absΔ; FF - open) are reported with 95% confidence intervals (95%CI).Results\n\nTEWL decreased under both RH conditions, whereas capacitance increased only at 60% RH. Under SSLHS, absΔTEWL (3 h-0 h) was associated with baseline TEWL (r = 0.661, 95%CI 0.44-0.81), capacitance (r = -0.504, 95%CI -0.70 to -0.23), and SEr (r = 0.518, 95%CI 0.25-0.71). During SSLHS, the FF film reduced absΔTEWL (mean difference -1.22 [95%CI -2.36, -0.09]) and increased absΔCapacitance (+2.20 [0.87, 3.54]) versus the open side. Exploratory subgroup analysis suggested larger differences in subjects classified as sensitive.Conclusion\n\nRapid low-humidity responses vary with baseline SC function, and an FF film without lotion modulates short-term responses to low humidity.",
  "abstract_shown": true,
  "affiliations": [
    "Biological Science Research, Kao Corporation, Ichikai-machi, Tochigi, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Junko Ishikawa",
      "orcid": "0009-0002-8373-4175"
    },
    {
      "affs": [
        0
      ],
      "name": "Akane Kawamoto",
      "orcid": "0009-0002-0687-1715"
    },
    {
      "affs": [
        0
      ],
      "name": "Urara Yokose"
    },
    {
      "affs": [
        0
      ],
      "name": "Noriyasu Ota",
      "orcid": "0000-0003-0428-7160"
    },
    {
      "affs": [
        0
      ],
      "name": "Takatoshi Murase"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0p5x1ta8xn6k6.bib",
  "cited_by": 0,
  "doi": "10.1111/srt.70398",
  "fulltext_url": "https://europepmc.org/articles/PMC13721170",
  "id": "0p5x1ta8xn6k6",
  "issns": [
    "0909-752X",
    "1600-0846"
  ],
  "landing_url": "https://europepmc.org/article/MED/42960976",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2708|Dermatology and Skin Diseases"
    ]
  ],
  "openalex": "W7224788066",
  "pdf_url": "https://europepmc.org/articles/PMC13721170?pdf=render",
  "pmcid": "PMC13721170",
  "pmid": "42960976",
  "published": "2026-10-30",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/0p5x1ta8xn6k6.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42960976",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960976"
    },
    {
      "first_seen": "2026-11-03T12:21:54Z",
      "native_id": "PMC13721170",
      "source": "pmc",
      "url": "https://doi.org/10.1111/srt.70398"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Dermatology and Skin Diseases",
      "subfield": "general"
    }
  ],
  "title": "Rapid Skin Responses to a Low Humidity Environment and the Benefits of a Fine Fiber Film.",
  "title_text": "Rapid Skin Responses to a Low Humidity Environment and the Benefits of a Fine Fiber Film.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:54Z",
  "url": "https://research.draconitic.com/paper/0p5x1ta8xn6k6",
  "venue": "Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)",
  "versions": []
}