{
  "abstract": "Melanoma is a highly aggressive cutaneous malignancy with significant metastatic potential, posing ongoing challenges in elucidating the molecular mechanisms driving its progression. Epithelial-mesenchymal transition (EMT) is a key process that enhances cancer cell migration and invasion, facilitating metastatic dissemination. Sirtuin 6 (SIRT6), a NAD⁺-dependent enzyme, has been reported to either promote or suppress EMT in a context-dependent manner; however, its function in melanoma remains poorly defined. We previously showed that SIRT6 is overexpressed in melanoma tissues and cells, where it contributes to tumor growth via an autophagy-dependent mechanism. In this study, we further investigated the role of SIRT6 in EMT using melanoma cells with stable overexpression or shRNA-mediated knockdown. Overexpression of SIRT6 enhanced cell proliferation and clonogenic survival and was associated with increased expression of mesenchymal markers and EMT-associated transcription factors. Conversely, SIRT6 knockdown significantly reduced the expression of these genes. Functionally, SIRT6 depletion markedly impaired cell migration and invasion, as demonstrated by wound-healing and Matrigel invasion assays. Collectively, these findings identify SIRT6 as a promoter of an invasive, mesenchymal phenotype in melanoma. Our results support a potential oncogenic role for SIRT6 and highlight its inhibition as a promising therapeutic strategy to limit melanoma progression and metastasis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, University of Wisconsin, Madison, WI, USA.",
    "William S. Middleton Memorial Veterans Hospital, Madison, WI, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liz M Garcia-Peterson",
      "orcid": "0000-0002-7231-280X"
    },
    {
      "affs": [
        0
      ],
      "name": "Amelia M Lemkuil",
      "orcid": "0009-0008-3208-353X"
    },
    {
      "affs": [
        0
      ],
      "name": "Mary A Ndiaye",
      "orcid": "0000-0002-5254-1840"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nihal Ahmad",
      "orcid": "0000-0002-4239-9887"
    },
    {
      "affs": [
        0
      ],
      "name": "Gagan Chhabra",
      "orcid": "0000-0001-5205-7218"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ppfz0etp4mzb.bib",
  "cited_by": 0,
  "doi": "10.1080/29944376.2026.2700162",
  "fulltext_url": "https://europepmc.org/articles/PMC13645373",
  "id": "0ppfz0etp4mzb",
  "issns": [
    "2994-4376"
  ],
  "landing_url": "https://europepmc.org/article/MED/42847091",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2717|Sirtuins and Resveratrol in Medicine"
    ]
  ],
  "openalex": "W7168085740",
  "pdf_url": "https://europepmc.org/articles/PMC13645373?pdf=render",
  "pmcid": "PMC13645373",
  "pmid": "42847091",
  "published": "2026-07-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0ppfz0etp4mzb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42847091",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42847091"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2717|Sirtuins and Resveratrol in Medicine",
      "subfield": "general"
    }
  ],
  "title": "SIRT6 promotes a mesenchymal, invasive phenotype in melanoma.",
  "title_text": "SIRT6 promotes a mesenchymal, invasive phenotype in melanoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/0ppfz0etp4mzb",
  "venue": "Journal of dermato-oncology",
  "versions": []
}