{
  "abstract": "Acute kidney injury (AKI) remains a major health concern globally, with ferroptosis being the most critical pathological change in proximal tubule cells (PTCs). However, no specific pharmacotherapies have been developed yet. Here, by combining databases (in vitro LINCS and in vivo MTDS) covering drug-altered gene profiles with ferroptosis-associated FerrDb, nicotinamide mononucleotide (NMN) was identified to target renal ferroptosis. Furthermore, PEGylation increased the preferential uptake of NMN in mice renal cortex, enhancing its alleviating effect on AKI. Through MALDI-MS-based spatially resolved metabolomics and SEAM analyses, NMN-PEG was found to augment peroxisomal function in PTCs via ACAA1, leading to increased β-oxidation of LCFAs and VLCFAs to mitigate ferroptosis and inflammation. Notably, ACAA1 also suppressed palmitoylation of FAR1 Cys111 to mediate NMN-PEG-improved lipid metabolism. Our study is the first to reveal the renal ferroptosis-targeting role of NMN-PEG and the underlying molecular mechanism, shedding new light on the development of novel AKI therapeutics.",
  "abstract_shown": true,
  "affiliations": [
    "Academy of Military Medical Sciences, Beijing 100850, China.",
    "Pingyuan Laboratory, Henan 453000, China.",
    "Department of Hematology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.",
    "Department of Nephrology, Chongqing Key Laboratory of Prevention and Treatment of Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.",
    "Medical Service Training Center, Chinese PLA General Hospital, Beijing 100853, China.",
    "CapitalBio Technology Corporation, Beijing 101111, China.",
    "Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.",
    "National Key Laboratoty of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing 100853, China."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yang Yue"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Changdong Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingyu Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaochang Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongjun Lin"
    },
    {
      "affs": [
        2
      ],
      "name": "Ming Niu"
    },
    {
      "affs": [
        3
      ],
      "name": "Aihong Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Shuiqin Gong"
    },
    {
      "affs": [
        4
      ],
      "name": "Lijing Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuke Cui"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaodan Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiangbo Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi He"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenhui Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Wen Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingqi Shi"
    },
    {
      "affs": [
        5
      ],
      "name": "Yanze Li"
    },
    {
      "affs": [
        5
      ],
      "name": "Xing Qin"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Xiangmei Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Liang Guo"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Shengqi Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0pwzevvysxbc0.bib",
  "cited_by": 0,
  "doi": "10.7150/ijbs.132234",
  "fulltext_url": "https://europepmc.org/articles/PMC13685766",
  "id": "0pwzevvysxbc0",
  "issns": [
    "1449-2288"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909988",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Ferroptosis and cancer prognosis"
    ]
  ],
  "openalex": "W7221435055",
  "pdf_url": "https://europepmc.org/articles/PMC13685766?pdf=render",
  "pmcid": "PMC13685766",
  "pmid": "42909988",
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0pwzevvysxbc0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42909988",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909988"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Ferroptosis and cancer prognosis",
      "subfield": "general"
    }
  ],
  "title": "PEGylated nicotinamide mononucleotide targeted ferroptosis in acute kidney injury by suppressing FAR1 palmitoylation in an ACAA1-dependent manner.",
  "title_text": "PEGylated nicotinamide mononucleotide targeted ferroptosis in acute kidney injury by suppressing FAR1 palmitoylation in an ACAA1-dependent manner.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/0pwzevvysxbc0",
  "venue": "International journal of biological sciences",
  "versions": []
}