{
  "abstract": "Polyvinyl chloride (PVC) is extensively used in advanced therapies due to its flexibility, chemical resistance, and biocompatibility. This study investigates the equivalency of three ionizing radiation sterilization technologies (gamma rays, X-rays, and electron beam) at 50 and 100 kGy on three medical-grade PVC formulations. A comprehensive analytical approach combining Electron Spin Resonance (ESR), Fourier Transform Infrared Spectroscopy (FTIR), colorimetry, and High-Performance Liquid Chromatography (HPLC) was employed. ESR revealed persistent polyenyl radicals (up to 60 days) influenced by ageing rather than irradiation technology or dose. FTIR-PCA demonstrated dose-dependent carbonyl growth (1708 cm⁻¹) from additive oxidation whereas PVC backbone signatures remained stable. Statistical analysis established that differences among technologies remain within acceptable equivalence margins. These findings confirm that gamma, X-ray, and e-beam irradiation preserve the chemical integrity of PVC formulations for medical device applications.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Samuel Dorey"
    },
    {
      "name": "Fabien Girard"
    },
    {
      "name": "Nathalie Dupuy"
    },
    {
      "name": "Celine Huart"
    },
    {
      "name": "Sylvain R.A. Marque"
    },
    {
      "name": "Blanche Krieguer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0qa7yt0z3he8j.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ejps.2026.107687",
  "fulltext_url": null,
  "id": "0qa7yt0z3he8j",
  "issns": [
    "0928-0987",
    "1879-0720"
  ],
  "landing_url": "https://hal.science/hal-05808155v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sde"
    ],
    [
      "hal",
      "1.sde.be"
    ],
    [
      "openalex",
      "2507|Polymer Science and PVC"
    ]
  ],
  "openalex": "W7221669519",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-19",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0qa7yt0z3he8j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:59Z",
      "native_id": "hal-05808155",
      "source": "hal",
      "url": "https://hal.science/hal-05808155v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sde.be",
      "subfield": "ecology"
    },
    {
      "field": "earth",
      "origin": "hal:0.sde",
      "subfield": "environmental-science"
    }
  ],
  "title": "Compatibility of PVC after irradiation: spectroscopic evaluation",
  "title_text": "Compatibility of PVC after irradiation: spectroscopic evaluation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:59Z",
  "url": "https://research.draconitic.com/paper/0qa7yt0z3he8j",
  "venue": "European Journal of Pharmaceutical Sciences",
  "versions": []
}