{
  "abstract": "Enabled by synthetic biology and metabolic engineering, microbial biomanufacturing is reshaping the production of food-related compounds by offering sustainable alternatives to resource-intensive extraction and conventional chemical synthesis. However, information linking food-related compounds to biosynthetic pathways and microbial biomanufacturing evidence remains fragmented across the literature and poorly represented in existing food-oriented resources, hindering cross-study comparison, evidence synthesis, and rational design of microbial production systems. Here, we present SynBioFooDB (https://synbiofoodb.biodesign.ac.cn/), a knowledgebase dedicated to synthetic biology-driven food biomanufacturing. SynBioFooDB integrates 74 237 food-related compounds with standardized chemical identities and annotations covering food occurrence, bioactivity, toxicity, and regulatory information. It further provides expert-curated biomanufacturing evidence for 1054 compounds from 5592 publications, linking microbial hosts, substrates, genetic modifications, and quantitative production metrics through structured and traceable records. The database also contains 2002 literature-reported biosynthetic pathways for 971 compounds, enabling comparison of alternative precursors, enzyme combinations, and pathway architectures. For compounds without literature-reported pathways, SynBioFooDB provides computationally predicted candidate pathways to facilitate pathway prioritization and experimental evaluation. By integrating compound-level context, biomanufacturing evidence, and biosynthetic pathway information, SynBioFooDB supports systematic exploration, comparison, and rational design of microbial production strategies for food-related compounds.",
  "abstract_shown": true,
  "affiliations": [
    "Biodesign Center, Key Laboratory of Engineering Biology for Low-carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences , Tianjin 300308 ,",
    "Haihe Laboratory of Synthetic Biology , Tianjin 300308 ,",
    "National Technology Innovation Center of Synthetic Biology , Tianjin 300308 ,",
    "College of Biotechnology, Tianjin University of Science and Technology , Tianjin 300457 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Fan Wei"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Xiaogui Deng"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Haoran Li"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Ruoyu Wang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Zhitao Mao",
      "orcid": "0000-0002-8160-2585"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yufeng Mao"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yushuo Liu"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Qishun Niu"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Yuxin Qin"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Jun Du"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Xiaoping Liao",
      "orcid": "0000-0002-9852-910X"
    },
    {
      "affs": [
        1
      ],
      "name": "Yu Bai"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Qianqian Yuan",
      "orcid": "0000-0002-0749-0749"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Hongwu Ma",
      "orcid": "0000-0001-5325-2314"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0qdwx6986x6hx.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1073",
  "fulltext_url": null,
  "id": "0qdwx6986x6hx",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1073/9002505",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Microbial Metabolic Engineering and Bioproduction"
    ]
  ],
  "openalex": "W7223788562",
  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1073/72528772/gkag1073.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/0qdwx6986x6hx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:50Z",
      "native_id": "10.1093/nar/gkag1073",
      "source": "crossref",
      "url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1073/9002505"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Microbial Metabolic Engineering and Bioproduction",
      "subfield": "molecular-biology"
    }
  ],
  "title": "SynBioFooDB: a comprehensive resource for synthetic biology-driven food biomanufacturing",
  "title_text": "SynBioFooDB: a comprehensive resource for synthetic biology-driven food biomanufacturing",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:50Z",
  "url": "https://research.draconitic.com/paper/0qdwx6986x6hx",
  "venue": "Nucleic Acids Research",
  "versions": []
}