{
  "abstract": "Background: Primary prevention of cardiovascular diseases (CVD) represents a priority given the growing disease burden. Polygenic risk scores (PRS) may have the potential of improving behaviors especially among individuals at high PRS-risk. The Personalised HeartCare (PHC) trial aims to assess the effect of PRS disclosure on lifestyle behaviors.\n\nMethods: PHC is a single-arm monocentric trial conducted at Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, enrolling healthy ≥40 years adults with low 10-year CVD risk (ClinicalTrials.gov NCT06888466). Primary endpoint is change in CardioVascular Health (CVH) assessed by Life’s Essential 8 (LE8, 0-100) at 12 months. At baseline, PRS testing was performed and genomic literacy was assessed using Vanderbilt PRS-Knowledge Scale (PRS‑KS:0 to 7, with 0-2=low). One month after PRS disclosure(T1), psychological responses were measured with FACToR questionnaire (negativity, uncertainty, privacy 0-12; positivity 0-16).Recruitment is finalized while follow-up is still ongoing.\n\nResults: 434 participants were enrolled (60% female, mean age 56±7.2). Mean LE8 score was 65.5±10.6, with 83% classified as intermediate CVH. Among 432 genotyped participants, 56 (13%) had high PRS and 376 (87%) non-high. Genomic literacy, assessed in 406 participants, showed mean PRS‑KS score of 4.6 ± 1.5, with no differences between PRS groups. At T1, mean FACToR scores across all participants were: negativity 1.3±1.8, uncertainty 2.0±2.2, privacy 1.0±1.5, positivity 9.6±3.4. High PRS recipients showed significantly greater negativity and uncertainty, and lower positivity compared with non-high PRS (all p < 0.001).\n\nConclusions: Baseline findings from the PHC trial describe a population with intermediate CVH and good Genomic literacy. Preliminary results show that high PRS disclosure is associated with emotional distress and uncertainty. Ongoing follow-up will clarify whether PRS disclosure influences lifestyle change.\n\nThanks to DARE-CUP:B53C22006320001\n\nKey messages: • High PRS disclosure for CVD is associated with significantly greater negativity and uncertainty in a pilot study in Italy, highlighting the need for tailored communication strategies.\n\n• Most participants had intermediate cardiovascular health at baseline, suggesting room for lifestyle improvement through PRS-based personalized prevention.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "abstract",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "L Proto"
    },
    {
      "name": "L Russo"
    },
    {
      "name": "R Galarducci"
    },
    {
      "name": "E Pascucci"
    },
    {
      "name": "G Antonini"
    },
    {
      "name": "G Liuzzo"
    },
    {
      "name": "T Pasciuto"
    },
    {
      "name": "R Amore"
    },
    {
      "name": "R Pastorino"
    },
    {
      "name": "S Boccia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0qh8gzd3p63ad.bib",
  "cited_by": 0,
  "doi": "10.1093/eurpub/ckag169.1103",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698287/",
  "id": "0qh8gzd3p63ad",
  "issns": [
    "1101-1262",
    "1464-360X"
  ],
  "landing_url": "https://doi.org/10.1093/eurpub/ckag169.1103",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "6. Poster Displays"
    ],
    [
      "heading",
      "AcademicSubjects/MED00860"
    ],
    [
      "heading",
      "AcademicSubjects/SOC01210"
    ],
    [
      "heading",
      "AcademicSubjects/SOC02610"
    ],
    [
      "heading",
      "DB. Chronic diseases, multimorbidity and non-communicable diseases"
    ],
    [
      "openalex",
      "1311|Nutrition, Genetics, and Disease"
    ]
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  "openalex": "W7223684961",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13698287/pdf/?tool=EBI",
  "pmcid": "PMC13698287",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/0qh8gzd3p63ad.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:11Z",
      "native_id": "PMC13698287",
      "source": "pmc",
      "url": "https://doi.org/10.1093/eurpub/ckag169.1103"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13698287",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13698287"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Nutrition, Genetics, and Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Personalised HeartCare Trial: Preliminary Results on Genomic Literacy and PRS Psychological Impact",
  "title_text": "Personalised HeartCare Trial: Preliminary Results on Genomic Literacy and PRS Psychological Impact",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:10Z",
  "url": "https://research.draconitic.com/paper/0qh8gzd3p63ad",
  "venue": "The European Journal of Public Health",
  "versions": []
}