{
  "abstract": "Persistent infection by helminths requires limiting inflammatory damage despite incomplete pathogen clearance, yet how helminths mobilize resident microbiota to establish this state remains unclear. Here we identify a cross-kingdom metabolic relay through which Trichinella spiralis promotes systemic disease tolerance. Infection selectively expanded Ligilactobacillus murinus and redirected microbial tryptophan metabolism toward indole-3-lactic acid (ILA), a direct ligand of the aryl hydrocarbon receptor (AhR). Antibiotic perturbation abrogated ILA production, AhR activation and Treg-Th17 remodeling, whereas transfer of helminth-conditioned fecal preparations or supplementation with L. murinus or ILA restored these responses. Pharmacological inhibition or genetic deletion of AhR eliminated the protection conferred by T. spiralis, L. murinus and ILA against endotoxin-induced lung injury. In lethal SARS-CoV-2 infection, oral ILA improved survival and limited pulmonary immunopathology without reducing viral burden, thereby uncoupling host protection from pathogen control. In a human COVID-19 cohort, ILA relative abundance remained inversely associated with IFN-γ after adjustment for available clinical covariates. These findings reveal that helminths can reprogram commensal metabolism to govern systemic immune tolerance and identify microbial ILA production as a tractable postbiotic strategy for limiting inflammatory tissue damage.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.",
    "College of Food Science and Engineering, Jilin University, Changchun, China.",
    "Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians University of Würzburg, Würzburg, Germany.",
    "ANSES, Laboratory for Animal Health, Maisons-Alfort, France.",
    "UMR BIPAR, Anses, Laboratoire de Santé Animale, INRAE, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.",
    "School of Life Sciences, Jilin University, Changchun, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ruohang Sun"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yi Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Nuo Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoxiao Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingbo Lv"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiufeng Zhao"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Pascal Boireau"
    },
    {
      "affs": [
        5
      ],
      "name": "Zeming Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Mingyuan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaolei Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuemin Jin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0qn960948dwr3.bib",
  "cited_by": 0,
  "doi": "10.1080/19490976.2026.2748132",
  "fulltext_url": "https://europepmc.org/articles/PMC13682397",
  "id": "0qn960948dwr3",
  "issns": [
    "1949-0976",
    "1949-0984"
  ],
  "landing_url": "https://europepmc.org/article/MED/42881529",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7222584228",
  "pdf_url": "https://europepmc.org/articles/PMC13682397?pdf=render",
  "pmcid": "PMC13682397",
  "pmid": "42881529",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0qn960948dwr3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42881529",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42881529"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "A helminth-microbiota metabolic relay promotes disease tolerance.",
  "title_text": "A helminth-microbiota metabolic relay promotes disease tolerance.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/0qn960948dwr3",
  "venue": "Gut microbes",
  "versions": []
}