{
  "abstract": "Regiodivergent dearomative hydroelementation (E = Si, B) of quinolines represent a powerful, atomeconomic strategy for the synthesis of biologically valuable 1,2- and 1,4-dihydroquinolines (DHQ) scaffolds. However, achieving such regiodivergent H[E] additions at the C2 and C4 positions within a unified catalytic system remains highly challenging. Herein, we report a simple [Rh(cod)Cl]2/PPh3 catalytic system that enables regioselective hydride incorporation dictated solely by the choice of hydrosilane (Ph2SiH2 vs. Me2RSiH, R = Et or Ph). While the Ph2SiH2-mediated 1,2-hydrosilylation protocol proceeds efficiently at 23 oC, the 1,4-hydrosilylation with Me2EtSiH requires a prolonged reaction time or an elevated temperature (23 to 50 oC) to achieve high yields. Preliminary mechanistic studies under the Ph2SiH2 vs. Me2PhSiH systems indicate that (i) chloro-free, phosphine-ligated Rh hydride species in situ generated during the initiation stage serves as the key resting species; (ii) a classic Chalk–Harrod sequence operates to yield the 1,2-DHQ irrespective of the hydrosilane used; (iii) the Me2PhSiH system promotes a facile isomerization of the kinetic 1,2-DHQ product to the 1,4-DHQ via an exclusive 3,4-hydrorhodation process; and (iv) the dearomative 1,2-hydrorhodation is reversible under the Ph2SiH2 system and the liberated 1,2-DHQ is completely resistant to subsequent isomerization.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, and Guangdong Provincial Key Laboratory of Catalysis",
    "Southern University of Science and Technology",
    "Department of Chemistry",
    "Guangdong-Technion Israel Institute of Technology",
    "Technion-Israel Institute of Technology"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Mei Shu"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Sehoon Park",
      "orcid": "0000-0003-0263-2733"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0qns6yf9ctr5y.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010954/v1",
  "fulltext_url": null,
  "id": "0qns6yf9ctr5y",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010954/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organoboron and organosilicon chemistry"
    ]
  ],
  "openalex": "W7223337791",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010954/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0qns6yf9ctr5y.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.26434/chemrxiv.15010954",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010954/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organoboron and organosilicon chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Hydrosilane-Dependent Regiodivergence for Rhodium-Catalyzed Dearomative Hydrosilylation of Quinolines",
  "title_text": "Hydrosilane-Dependent Regiodivergence for Rhodium-Catalyzed Dearomative Hydrosilylation of Quinolines",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/0qns6yf9ctr5y",
  "venue": "ChemRxiv",
  "versions": []
}