{
  "abstract": "Treatment approaches for pancreatic adenocarcinoma, an aggressive disease with poor prognosis, are evolving beyond cytotoxic chemotherapy. Recent advances in RAS targeting with small molecules are redefining therapeutic paradigms.\n\nTreatment approaches for pancreatic adenocarcinoma, an aggressive disease with poor prognosis, are evolving beyond cytotoxic chemotherapy. In this Perspective, Samuel Soff and Eileen O'Reilly discuss recent breakthroughs and clinical trial results of RAS-targeting small molecule inhibitors, as well as the challenges of treatment resistance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, Weill Cornell Medicine, New York, New York, United States of America",
    "Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America"
  ],
  "article_type": "Perspective",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Samuel P. Soff",
      "orcid": "0000-0001-5851-6075"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Eileen M. O’Reilly",
      "orcid": "0000-0002-8076-9199"
    }
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  "bibtex": "https://research.draconitic.com/paper/0qvtx984bx3na.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pmed.1005283",
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    "1549-1277"
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  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Basic Cancer Research"
    ],
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      "heading",
      "Cancer Chemotherapy"
    ],
    [
      "heading",
      "Cancer Treatment"
    ],
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      "heading",
      "Cancers and Neoplasms"
    ],
    [
      "heading",
      "Chemotherapy"
    ],
    [
      "heading",
      "Clinical Medicine"
    ],
    [
      "heading",
      "Clinical Oncology"
    ],
    [
      "heading",
      "Colorectal Cancer"
    ],
    [
      "heading",
      "Drug Therapy"
    ],
    [
      "heading",
      "Extraction Techniques"
    ],
    [
      "heading",
      "Gastrointestinal Tumors"
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    [
      "heading",
      "Lung and Intrathoracic Tumors"
    ],
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      "Metastasis"
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      "heading",
      "Non-Small Cell Lung Cancer"
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    [
      "heading",
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    ],
    [
      "heading",
      "Pancreatic Cancer"
    ],
    [
      "heading",
      "Perspective"
    ],
    [
      "heading",
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    ],
    [
      "heading",
      "Research and Analysis Methods"
    ],
    [
      "heading",
      "Solid-Phase Extraction"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Clinical oncology/Cancer chemotherapy"
    ],
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      "plos",
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    ],
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      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Colorectal cancer"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Gastrointestinal tumors/Pancreatic cancer"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Lung and intrathoracic tumors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Lung and intrathoracic tumors/Non-small cell lung cancer"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Clinical oncology/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Metastasis"
    ],
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      "plos",
      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Chemotherapy/Cancer chemotherapy"
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      "plos",
      "/Research and analysis methods/Extraction techniques/Solid-phase extraction"
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  "pdf_url": "https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1005283&type=printable",
  "pmcid": "PMC13730419",
  "pmid": "42956081",
  "published": "2026-10-29",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/0qvtx984bx3na.ris",
  "sources": [
    {
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      "url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005283"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:oncology",
      "subfield": "oncology"
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  ],
  "title": "Pancreatic cancer: The RAS paradigm shift",
  "title_text": "Pancreatic cancer: The RAS paradigm shift",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:59Z",
  "url": "https://research.draconitic.com/paper/0qvtx984bx3na",
  "venue": "PLOS Medicine",
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}