{
  "abstract": "Process analytical technologies (PATs) are increasingly vital tools in process research and development, enabling realtime monitoring of a reaction’s chemical and physical parameters. Although numerous commercial PATs exist, many are limited by sampling frequency, material consumption, or requiring unique chemical labels for spectroscopic analysis. Herein, we report a rapid, label-free analytical sampling platform that integrates fast high-pressure liquid chromatography (HPLC) with electrospray ionizationmass spectrometry (ESI-MS) for the direct, real-time monitoring of chemical reactions. Reactions are pumped into a four-port nanovolume injection valve and are injected onto short LC columns at high mobile phase flow rates, which enables chromatographic separations on the time-scale of 6–20 seconds. We demonstrate the utility of this technology by monitoring two rapid reactions relevant to the pharmaceutical industry: a photocatalytic thiol–ene reaction and a metallaphotoredox aryl sulfonamidation reaction. In each case, data-rich reaction progress profiles are obtained for monitoring the reaction progress in real-time, demonstrating the platform’s capability to deliver detailed reaction insights with minimal sample consumed (4 nL injection-1). Its modular design is adaptable to different reactor geometries and scales, while maintaining device simplicity to enable straightforward integration into existing workflows in industrial settings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry",
    "University of Michigan",
    "Process Research and Development",
    "AbbVie Inc.",
    "University of British Columbia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ryan T. Snyder"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Trevor J. Kempen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yue Xin"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Juan Vazquez-Lopez"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "G. Thomas Knecht"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Kaid C. Harper"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Westin H. Morrill"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Bradley A. Greiner"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Nicholas G. W. Cowper"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Anna V. Bay"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Kyle T. Jaunich"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Corey R. J. Stephenson"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Robert T. Kennedy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0rr30v5yb0r98.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010688/v1",
  "fulltext_url": null,
  "id": "0rr30v5yb0r98",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010688/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1607|Mass Spectrometry Techniques and Applications"
    ]
  ],
  "openalex": "W7223061967",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010688/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0rr30v5yb0r98.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010688",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010688/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Mass Spectrometry Techniques and Applications",
      "subfield": "physical"
    }
  ],
  "title": "Fast Liquid Chromatography for Real-Time Process Monitoring of Chemical Reactions in Batch and Flow",
  "title_text": "Fast Liquid Chromatography for Real-Time Process Monitoring of Chemical Reactions in Batch and Flow",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/0rr30v5yb0r98",
  "venue": "ChemRxiv",
  "versions": []
}