{
  "abstract": "Background: The Fibrosis-4 Index (FIB-4) is a non-invasive tool used to assess advanced liver fibrosis. Although liver fibrosis has been linked to heart disease, its relationship with cardiac structure and function remains unclear.\n\nObjectives: This study examined associations of FIB-4 with incident heart disease and cardiac morpho-functional phenotypes and explored whether cardiac phenotypes statistically accounted for part of the association.\n\nMethods: In this prospective cohort study using the UK Biobank, 416,001 participants without known heart or liver disease at baseline (mean age 56.15 ± 8.09 years; 55.78% female) were followed for up to 17 years. FIB-4, calculated from age, AST, ALT, and platelet count, was analyzed continuously and using a high-risk threshold of >2.67. Incident coronary heart disease, cardiac arrhythmias (CA), and heart failure (HF) were identified from linked records. A subset of 33,927 participants underwent cardiovascular magnetic resonance (CMR) imaging a median of 10.20 years after baseline.\n\nResults: Over a median follow-up of 14.61 years, 57,207 participants (13.75%) developed heart disease. Higher FIB-4 was associated with CA (HR = 1.32, 95% CI 1.24–1.41), HF (HR = 1.29, 95% CI 1.14–1.47), greater LV mass ( β =0.014, 95% CI 0.0003–0.027), chamber dilation, reduced atrial ejection fractions, and LV remodeling. Exploratory pathway analysis indicated that LA ejection fraction statistically accounted for 36.38% of the FIB-4–CA/HF association; causal mediation cannot be inferred.\n\nConclusion: Elevated FIB-4 was associated with incident CA and HF and with adverse CMR phenotypes. Exploratory pathway results were consistent with indirect pathways through cardiac remodeling, but the observational design and single CMR assessment preclude causal or temporal interpretation. FIB-4 may help identify people at higher cardiovascular risk.",
  "abstract_shown": true,
  "affiliations": [
    "Public Health Science and Engineering College, Tianjin University of Traditional Chinese Medicine",
    "Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet",
    "National Key Laboratory of Chinese Medicine Modernization, State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine",
    "Haihe Laboratory of Modern Chinese Medicine",
    "Center of Gerontology and Geriatrics, West China Hospital, Sichuan University",
    "National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University",
    "Department of Neurology, University of Pennsylvania Perelman School of Medicine"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rongrong Yang"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yubo Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Xingxu Yan"
    },
    {
      "affs": [
        1,
        4,
        5
      ],
      "name": "Jiao Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Sakura Sakakibara"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Abigail Dove"
    },
    {
      "affs": [
        1
      ],
      "name": "Weili Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0sbmf4wr2tvx3.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1777872",
  "fulltext_url": "https://europepmc.org/articles/PMC13683155",
  "id": "0sbmf4wr2tvx3",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1777872/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7220841657",
  "pdf_url": "https://europepmc.org/articles/PMC13683155?pdf=render",
  "pmcid": "PMC13683155",
  "pmid": "42908793",
  "published": "2026-10-07",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/0sbmf4wr2tvx3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.1777872",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1777872/full"
    },
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42908793",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908793"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Linking liver fibrosis to cardiac structure, function, and heart disease: a community-based fibrosis-4 index study",
  "title_text": "Linking liver fibrosis to cardiac structure, function, and heart disease: a community-based fibrosis-4 index study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/0sbmf4wr2tvx3",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}