{
  "abstract": "ObjectiveImpulse control disorders (ICDs) are clinically important nonmotor features of Parkinsons disease (PD). Tremor-dominant PD (TD-PD) has been associated with greater cerebello-thalamo-cortical involvement, whereas postural instability/gait difficulty-dominant PD (PIGD-PD) has been linked to more prominent basal ganglia and frontostriatal dysfunction. We therefore examined whether ICD symptoms differ by motor phenotypes.\n\nMethodsThis cross-sectional study analyzed baseline data from the Parkinsons Precision Medicine Initiative (PPMI). Motor subtype classification was based on Movement Disorder Society-Unified Parkinsons Disease Rating Scale (MDS-UPDRS) criteria. ICD symptoms were assessed using the Questionnaire for Impulsive-Compulsive Disorders in Parkinsons Disease-Current Short Form (QUIP-CS) and evaluated across multiple levels of analysis using the standard screening definition and normalized QUIP-CS scores analyzed categorically and continuously. Temporal-alignment, subgroup, multivariable, and Bayesian analyses were performed to assess the robustness of the primary findings.\n\nResultsWe analyzed 305 participants (173 TD-PD, 132 PIGD-PD). Screening-defined ICD positivity was similar between subtypes (21.4% vs 21.2%, OR = 1.01, 95% CI 0.58-1.76, p = 0.970). Continuous and categorical normalized QUIP-CS scores likewise did not differ between groups (continuous score: 0.0338 vs 0.0384, p = 0.674; categorical score: 3.5% vs 4.5%, p = 0.632). Temporally aligned, subgroup, and multivariable sensitivity analyses consistently supported the primary finding, and Bayesian analysis provided moderate evidence supporting the null hypothesis (BF01 = 7.21).\n\nConclusionsICD symptoms do not differ between TD-PD and PIGD-PD motor subtypes in early PD. These findings suggest that motor subtype-associated differences in cerebellar involvement do not substantially influence ICD symptoms in early PD.",
  "abstract_shown": true,
  "affiliations": [
    "Baylor College of Medicine"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "M. E. Chhotani"
    },
    {
      "name": "W. Saban"
    },
    {
      "name": "M. Rossi"
    },
    {
      "name": "S.-H. Kuo"
    },
    {
      "name": "L. Montaser-Kouhsari"
    },
    {
      "affs": [
        0
      ],
      "name": "C.-Y. R. Lin"
    },
    {
      "name": "Parkinsons Precision Medicine Initiative"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0se2fjvw789ay.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.04.26362266",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362266v1.full",
  "id": "0se2fjvw789ay",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362266v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2728|Parkinson's Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7204095062",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362266v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0se2fjvw789ay.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:03Z",
      "native_id": "10.64898/2026.09.04.26362266",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362266v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes",
  "title_text": "Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:03Z",
  "url": "https://research.draconitic.com/paper/0se2fjvw789ay",
  "venue": "medRxiv",
  "versions": []
}