{
  "abstract": "Calcium silicate-based cements are increasingly used in vital pulp therapy, endodontic repair, and regenerative procedures, but their selection remains complicated by differences in formulation, hydration behavior, mechanical maturation, biological activity, and clinical evidence. This review integrates physicochemical, mechanical, biological, and clinical data on mineral trioxide aggregate (MTA), Biodentine, EndoSequence Root Repair Material (ERRM), and calcium-enriched mixture (CEM) cement within a mechanistic-to-clinical framework linking material composition and hydration with ion release, alkalization, interfacial mineralization, cellular responses, and indication-specific performance. MTA remains the reference material with the most mature clinical evidence, although conventional formulations remain limited by prolonged setting, handling difficulties, and discoloration risk. Biodentine combines relatively rapid setting, favorable handling and esthetic characteristics, and pronounced early bioactivity. ERRM provides a convenient premixed formulation and promising mechanical, sealing, and biological performance, whereas CEM cement combines calcium- and phosphate-related bioactivity, antimicrobial activity, and encouraging clinical outcomes, particularly in vital pulp therapy. Across all materials, improvements in individual properties are accompanied by formulation-dependent trade-offs involving solubility, porosity, radiopacity, maturation kinetics, and biological response. Substantial methodological heterogeneity limits direct numerical ranking. Material selection should therefore be indication-specific and integrate material behavior with the maturity of supporting clinical evidence.",
  "abstract_shown": true,
  "affiliations": [
    "Student Scientific Club of the Department of Orthodontics, Medical University of Lodz, 92-213 Lodz, Poland",
    "Central Teaching Hospital, Medical University of Lodz, 92-213 Lodz, Poland",
    "College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China",
    "Key Laboratory of Molecular Biophysics of the Ministry of Education, Wuhan 430074, China",
    "Department of Orthodontics, Medical University of Lodz, 92-213 Lodz, Poland",
    "Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 90-419 Lodz, Poland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Natalia Sędek"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Adamska"
    },
    {
      "affs": [
        1
      ],
      "name": "Kamil Saramowicz",
      "orcid": "0009-0000-0395-5986"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Pengyu Zhao",
      "orcid": "0009-0002-2802-4429"
    },
    {
      "affs": [
        4
      ],
      "name": "Konrad Małkiewicz"
    },
    {
      "affs": [
        5
      ],
      "name": "Wioletta Rozpędek-Kamińska",
      "orcid": "0000-0001-9206-1203"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0skwx58de5npm.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms272110042",
  "fulltext_url": null,
  "id": "0skwx58de5npm",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/10042",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/0skwx58de5npm.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:27Z",
      "native_id": "10.3390/ijms272110042",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/10042"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Selected Calcium Silicate-Based Endodontic Cements: From Physicochemical Properties and Molecular Bioactivity to Indication-Specific Clinical Performance",
  "title_text": "Selected Calcium Silicate-Based Endodontic Cements: From Physicochemical Properties and Molecular Bioactivity to Indication-Specific Clinical Performance",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:27Z",
  "url": "https://research.draconitic.com/paper/0skwx58de5npm",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}