{
  "abstract": "Background: Endovascular therapy (EVT) is effective for acute anterior circulation large vessel occlusion (LVO), yet futile recanalization remains common. Identifying its predictors is essential to optimize patient selection.\n\nMethods: This retrospective cohort study included 311 patients with anterior circulation LVO who underwent successful EVT. Patients were divided into an effective recanalization group (90-day modified Rankin Scale (mRS) score ≤ 2, n = 150) and a futile recanalization group (mRS > 2, n = 161). Clinical, imaging, and procedural variables were compared. Multivariate logistic regression was used to identify independent predictors, and a predictive model was evaluated using receiver operating characteristic (ROC) curve analysis.\n\nResults: Baseline comparisons between the two groups showed significant differences in age, sex, atrial fibrillation, stress hyperglycemia ratio (SHR), C-reactive protein, admission National Institutes of Health Stroke Scale (NIHSS) score, diffusion-weighted imaging (DWI) infarct volume, DWI-Alberta Stroke Program Early CT Score (DWI-ASPECTS) score, number of procedure attempts, and procedure time. Univariate logistic regression and multivariate logistic regression identified admission NIHSS score (OR = 1.381, 95% CI: 1.113–1.713, p = 0.003), DWI infarct volume (OR = 1.057, 95% CI: 1.025–1.090, p < 0.001), DWI-ASPECT score (OR = 69.240, 95% CI: 9.819–488.254, p < 0.001), procedure time (OR = 1.011, 95% CI: 1.005–1.018, p < 0.001), and SHR (OR = 3.447, 95% CI: 1.302–9.129, p = 0.013) as independent predictors of futile recanalization. A combined model incorporating these five predictors achieved an area under the curve (AUC) of 0.815 (sensitivity: 0.789, specificity: 0.787, Youden index: 0.576).\n\nConclusion: Admission NIHSS score, SHR, DWI infarct volume, DWI-ASPECT score, and procedure time are independent predictors of futile recanalization after EVT for anterior circulation LVO stroke. Higher NIHSS score, elevated SHR, larger infarct volume, lower DWI-ASPECT score, and prolonged procedure time increase the risk of poor functional outcome despite successful reperfusion.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Heyuan Hospital of Traditional Chinese Medicine , ,",
    "Heyuan People’s Hospital , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yangchun Wen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xi Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiujing Liao"
    },
    {
      "affs": [
        1
      ],
      "name": "Guanghong Zhong"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongli Gu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jia Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Ying Xie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0sztvy0ckdkyx.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1777164",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661445/?tool=EBI",
  "id": "0sztvy0ckdkyx",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13661445",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7214887454",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661445/pdf/?tool=EBI",
  "pmcid": "PMC13661445",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/0sztvy0ckdkyx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "PMC:PMC13661445",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13661445"
    },
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1777164",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1777164/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Predictors of futile recanalization following endovascular therapy for acute anterior circulation large vessel occlusion stroke: a retrospective cohort study",
  "title_text": "Predictors of futile recanalization following endovascular therapy for acute anterior circulation large vessel occlusion stroke: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:16Z",
  "url": "https://research.draconitic.com/paper/0sztvy0ckdkyx",
  "venue": "Frontiers in neurology",
  "versions": []
}