{
  "abstract": "A CuBr-catalyzed one-pot protocol provides access to decahydroquinoxaline-based bis(propargylamines) from readily available terminal alkynes, aromatic aldehydes, and a C2symmetric chiral diamine. The three-component coupling proceeds at 120 °C within 12 h, affording the products in 58–93% yields with diastereomeric ratios of up to 99:1. The synthetic utility of the protocol is illustrated by the ZnI2-mediated conversion of a representative bis(propargylamine) (7a) into the corresponding axially chiral allene (8a) with 90% ee. This approach enables the stereoselective construction of bis(propargylamines) and demonstrates their application as precursors to axially chiral allenes.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmacy",
    "University of Wyoming",
    "School of Chemistry",
    "University of Hyderabad"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Laxman Alakonda",
      "orcid": "0009-0000-6749-0479"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Mariappan Periasamy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0t8h02sh5htg7.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009369/v1",
  "fulltext_url": null,
  "id": "0t8h02sh5htg7",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009369/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Asymmetric Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7214107363",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009369/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0t8h02sh5htg7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009369",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009369/v2"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Asymmetric Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "CuBr-Catalyzed Enantioselective Synthesis of Decahydroquinoxaline-Based",
  "title_text": "CuBr-Catalyzed Enantioselective Synthesis of Decahydroquinoxaline-Based",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/0t8h02sh5htg7",
  "venue": "ChemRxiv",
  "versions": []
}