{ "abstract": "Therapies built on mitochondrial transfer hold promise for repairing dysfunctional, energy-deficient cells. Still, mesenchymal stem cells used as mitochondrial donors are limited by poor engraftment, risk of aberrant differentiation, and low transfer efficiency. Herein, we constructed photosynthesis-empowered cross-kingdom chimeric stem cells (PCSs; \"mitochondrial battery\") by introducing plant-derived thylakoid-based artificial nuclei plus FGF21-encoding messenger RNA (mRNA) into enucleated bone marrow mesenchymal stem cells. Photosynthetic activity enhances mitochondrial transfer to restore metabolism in damaged cells and elevates anabolism to increase FGF21 production. Sustained FGF21 release promotes mitochondrial biogenesis and sustains long-term cellular energy homeostasis. Mouse and porcine wound healing models demonstrate that PCSs recharge cellular energy to accelerate wound repair. This light-activated cellular photosynthetic platform supports modular mRNA programmability, shows no engraftment or aberrant differentiation, and allows repeated administration for diverse therapeutic applications.", "abstract_shown": true, "affiliations": [ "Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, PR China.", "Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou 310000, China.", "Plastic and Cosmetic Surgery Department, Shenzhen University General Hospital, Shenzhen, China.", "Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.", "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.", "Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, Zhejiang 310009, China.", "Shanghai National Center for Applied Mathematics (SJTU Center) & Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.", "College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.", "ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, Zhejiang 311215, China." ], "article_type": "Research Article", "arxiv": null, "author_total": 12, "authors": [ { "affs": [ 0 ], "name": "Zhengtai Chen", "orcid": "0009-0009-3357-1524" }, { "affs": [ 1 ], "name": "Hanxiao Sun", "orcid": "0009-0001-9355-0380" }, { "affs": [ 0 ], "name": "Yuanyang Zheng", "orcid": "0009-0003-6916-5444" }, { "affs": [ 0 ], "name": "Xuan Jiang", "orcid": "0009-0007-4817-4682" }, { "affs": [ 1 ], "name": "Yan He" }, { "affs": [ 2, 3 ], "name": "Kai Ye", "orcid": "0009-0004-1500-0000" }, { "affs": [ 1 ], "name": "Yufan Zhang", "orcid": "0000-0002-1014-5073" }, { "affs": [ 4, 5 ], "name": "Zhengwei Mao", "orcid": "0000-0001-7990-2856" }, { "affs": [ 6 ], "name": "Ziyi Zhou", "orcid": "0000-0002-8267-8178" }, { "affs": [ 0 ], "name": "Xiaoxi Lin", "orcid": "0000-0002-7325-1367" }, { "affs": [ 1 ], "name": "Chenggang Yi", "orcid": "0000-0002-9722-0872" }, { "affs": [ 1, 7, 8 ], "name": "Wei Wang", "orcid": "0000-0003-2183-455X" } ], "bibtex": "https://research.draconitic.com/paper/0tbks650hdvnq.bib", "cited_by": 0, "doi": "10.1126/sciadv.aef8069", "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721958/?tool=EBI", "id": "0tbks650hdvnq", "issns": [ "2375-2548" ], "landing_url": "https://www.science.org/doi/abs/10.1126/sciadv.aef8069", "language": "eng", "licence": "CC-BY-NC", "licence_label": "CC BY-NC", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Biomedicine and Life Sciences" ], [ "heading", "Cell Biology" ], [ "heading", "Research Article" ], [ "heading", "SciAdv r-articles" ], [ "heading", "Stem Cells" ] ], "openalex": null, "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721958/pdf/?tool=EBI", "pmcid": "PMC13721958", "pmid": "42962029", "published": "2026-10-30", "publisher": "American Association for the Advancement of Science (AAAS)", "ris": "https://research.draconitic.com/paper/0tbks650hdvnq.ris", "sources": [ { "first_seen": "2026-10-31T00:20:30Z", "native_id": "10.1126/sciadv.aef8069", "source": "feed-science", "url": "https://www.science.org/doi/abs/10.1126/sciadv.aef8069" }, { "first_seen": "2026-10-31T00:20:32Z", "native_id": "10.1126/sciadv.aef8069", "source": "crossref", "url": "https://www.science.org/doi/10.1126/sciadv.aef8069" }, { "first_seen": "2026-10-31T12:21:37Z", "native_id": "PMC:PMC13721958", "source": "europepmc", "url": "https://europepmc.org/article/PMC/PMC13721958" }, { "first_seen": "2026-11-02T03:21:21Z", "native_id": "MED:42962029", "source": "europepmc", "url": "https://europepmc.org/article/MED/42962029" }, { "first_seen": "2026-11-03T12:22:33Z", "native_id": "PMC13721958", "source": "pmc", "url": "https://doi.org/10.1126/sciadv.aef8069" } ], "subjects": [ { "field": "biology", "origin": "heading:Cell Biology", "subfield": "cell-biology" }, { "field": "biology", "origin": "heading:Stem Cells", "subfield": "developmental-biology" } ], "title": "Photosynthetic chimeric stem cells function as mitochondrial batteries", "title_text": "Photosynthetic chimeric stem cells function as mitochondrial batteries", "type": "peer-reviewed", "updated_at": "2026-11-03T12:22:33Z", "url": "https://research.draconitic.com/paper/0tbks650hdvnq", "venue": "Science Advances", "versions": [] }