{
  "abstract": "Pathogenic germline variants in BRCA2 are associated with increased susceptibility to pancreatic ductal adenocarcinoma and may prompt pancreatic surveillance in selected high-risk individuals. Whether BRCA2 status increases the prevalence or alters the biological behavior of intraductal papillary mucinous neoplasms (IPMNs) remains uncertain. We report a 71-year-old Latin American woman with a reported heterozygous pathogenic BRCA2 variant and a remote history of stage IA hormone receptor-positive, HER2-negative breast carcinoma. The original molecular genetics report was unavailable; therefore, the exact variant designation, testing platform, laboratory classification, and American College of Medical Genetics and Genomics (ACMG)/Association of Molecular Pathology (AMP) evidence could not be independently verified. In June 2025, during long-term oncologic follow-up, positron emission tomography-computed tomography incidentally identified a 21×21 mm pancreatic tail cyst. Magnetic resonance cholangiopancreatography (MRCP) in July 2025 demonstrated a 22×20 mm cyst communicating with the main pancreatic duct (MPD), which measured 5 mm. Endoscopic ultrasound (EUS) demonstrated a 20×23 mm septated cyst without mural nodules or a solid component. Serum carbohydrate antigen 19-9 (CA 19-9) was 21.4 U/mL. Cyst fluid glucose was 12 mg/dL, amylase 316 U/L, and carcinoembryonic antigen (CEA) 247 ng/mL. Cytologic examination and an adequate cell-block specimen obtained by EUS-guided fine-needle aspiration (EUS-FNA) demonstrated papillary mucinous epithelium with gastric-type features, favoring a low-grade IPMN. No immunohistochemical studies were performed, and the specimens were evaluated by a gastrointestinal pathologist. The case was reviewed by a multidisciplinary team in August 2025. The 5 mm MPD represented a relative indication for surgery under the 2018 European evidence-based guidelines and a worrisome feature under contemporary international criteria, but no absolute or high-risk indication for resection was identified. Surveillance was selected. Computed tomography (CT) in December 2025 showed a stable 22×20 mm cyst and a 5 mm MPD; serum CA 19-9 was 24.7 U/mL. In May 2026, the cyst measured 22×21 mm, and the MPD remained 5 mm. The patient remained clinically stable and asymptomatic without pancreatitis, obstructive jaundice, abdominal pain, weight loss, or other symptoms attributable to the lesion. This case illustrates the integration of lesion-specific morphology, ductal anatomy, pathology, longitudinal imaging, and hereditary-risk context without using reported BRCA2 status alone as an indication for pancreatic resection.",
  "abstract_shown": true,
  "affiliations": [
    "Gastrointestinal Endoscopy, Hospital Regional de Alta Especialidad Bicentenario de la Independencia, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Tultitlán, MEX.",
    "Pathology, Hospital Regional de Alta Especialidad Bicentenario de la Independencia, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Tultitlán, MEX."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Julio C Balderas-Ortega"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoeli Escandon-Espinoza"
    },
    {
      "affs": [
        0
      ],
      "name": "Katia Lopez Garcia"
    },
    {
      "affs": [
        1
      ],
      "name": "Gabriela Jasso Guerrero"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0tdt7rsmm4d28.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116881",
  "fulltext_url": "https://europepmc.org/articles/PMC13695697",
  "id": "0tdt7rsmm4d28",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928716",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7214367750",
  "pdf_url": "https://europepmc.org/articles/PMC13695697?pdf=render",
  "pmcid": "PMC13695697",
  "pmid": "42928716",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0tdt7rsmm4d28.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928716",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928716"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Pancreatic and Hepatic Oncology Research",
      "subfield": "oncology"
    }
  ],
  "title": "Pancreatic Intraductal Papillary Mucinous Neoplasm in a Carrier of a Reported Pathogenic BRCA2 Variant: Diagnostic Considerations and Management Using European and International Guidelines.",
  "title_text": "Pancreatic Intraductal Papillary Mucinous Neoplasm in a Carrier of a Reported Pathogenic BRCA2 Variant: Diagnostic Considerations and Management Using European and International Guidelines.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/0tdt7rsmm4d28",
  "venue": "Cureus",
  "versions": []
}