{ "abstract": "Background: Pregnancy in women with SLE is considered high risk, particularly in the presence of active disease, organ damage or lupus anticoagulant (LA). Improvements in SLE and obstetric management may have enhanced outcomes.\n\nMethods: We compared pregnancies from the prospective GR2 (Groupe de Recherche sur la Grossesse et les Maladies Rares) cohort with those from the French general population using perinatal survey (Enquêtes Nationales Périnatales (ENP)) data. Eligible pregnancies resulted in a birth ≥22 weeks of gestation (WG) or ≥500 g, in accordance with the ENP inclusion criteria. Each GR2 pregnancy was matched with four ENP pregnancies based on maternal age, parity, number of fetuses and region. Live birth rates were evaluated after excluding minors, anonymous births and refusals. Adverse pregnancy outcomes (APOs) were assessed among live births with complete medical records and were defined as placental insufficiency-related preterm birth, severe small-for-gestational-age infant (birth weight <3rd percentile) or neonatal death.\n\nResults: We matched 430 GR2 pregnancies to 1720 ENP pregnancies. At inclusion, 336/397 (84.6%) women had no clinical lupus activity, 327/385 (84.9%) had no organ damage, 68/428 (15.9%) were LA-positive and 417/430 (97.0%) received hydroxychloroquine. Live births occurred in 423/430 (98.4%) GR2 pregnancies versus 1667/1720 (97.0%) ENP pregnancies (OR=1.49 (0.64 to 3.45); p=0.14). APOs occurred in 75/406 (18.5%) SLE pregnancies versus 134/1629 (8.2%) ENP pregnancies (OR=2.53 (1.86 to 3.44); p<0.001). APOs remained higher in GR2 pregnancies without disease activity, organ damage or LA positivity (30/209; 14.4%) than in ENP pregnancies (p<0.01). Univariate analysis identified SLE, nulliparity, smoking, chronic hypertension, twin pregnancy and fertility treatment as APO-associated factors. In multivariate analysis, SLE remained independently associated with APOs (aOR=2.91 (2.06 to 4.09); p<0.001).\n\nConclusion: Among pregnancies progressing beyond 22 WG (or birth weight ≥500 g), live birth rates were comparable to those in the general population, but APOs were more than two times as frequent in women with SLE.\n\nTrial registration number: NCT02450396.", "abstract_shown": true, "affiliations": [ "Internal Medicine, CHU Amiens-Picardie, Amiens, France", "Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France", "Department of Internal Medicine, Université de Paris, Paris, France", "Center for Research in Epidemiology and Statistics (CRESS), Université Paris Cité, Paris, France", "Service de Médecine Interne, Centre Hospitalier Régional Universitaire de Tours, Tours, France", "Center for Research in Epidemiology and Statistics (CRESS), Obstetric Perinatal Pediatric Life Course Epidemiology (OPPaLE), Paris, France", "Maternité Port-Royal, AP-HP, Paris, France", "Department of Internal Medicine and Infectious Diseases, Bordeaux University Hospital, Pessac, France", "UMR 5164, Bordeaux, France", "Universite Paris Cite, Paris, France", "Internal Medicine, Centre Hospitalier Universitaire Grenoble, Michallon Hospital, Grenoble, France", "Service d’Infectiologie, Centre Hospitalier Annecy Genevois, Épagny Metz-Tessy, France", "Service de Médecine interne, Centre Hospitalier Universitaire de La Réunion, Saint-Denis, France", "Service de Rhumatologie, Centre Hospitalier Universitaire de Bordeaux inflammatoires Systémiques Rares de l’Est et du Sud-Ouest, Bordeaux, France", "School of Medicine, Lille University, Lille, France", "Service de Médecine Interne, Hôpital Robert Schuman, Vantoux, France", "Service de Médecine Interne, Marseille, France", "Service de Néphrologie, Centre Hospitalier Universitaire de Nîmes, Nimes, France", "Service de Médecine Interne, Groupe Hospitalier du Havre, Le Havre, France", "Service de Médecine Interne, Centre Hospitalier Universitaire de Poitiers, Poitiers, France", "Internal Medicine, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France", "Service de Rhumatologie, Centre Hospitalier Universitaire de Nice, Nice, France", "Service de Médecine Interne, Hôpital Robert Debré, Reims, France", "Centre Hospitalier Universitaire de Toulouse, Toulouse, France", "Department of Medicine, University of Padova, Padova, Italy", "Department of Internal Medicine, APHP, Paris, France", "Centre Hospitalier Universitaire de Bordeaux, Talence, France", "Hopital Cochin, Paris, France" ], "article_type": "research article", "arxiv": null, "author_total": 30, "authors": [ { "affs": [ 0 ], "name": "Amandine Dernoncourt", "orcid": "0000-0003-0829-8764" }, { "affs": [ 1 ], "name": "Jean Schmidt" }, { "affs": [ 2 ], "name": "Gaëlle Guettrot-Imbert" }, { "affs": [ 3 ], "name": "Grégoire Martin De Frémont" }, { "affs": [ 3, 4 ], "name": "Anne Murarasu" }, { "affs": [ 5 ], "name": "Marie Viaud" }, { "affs": [ 6 ], "name": "Camille Le Ray" }, { "affs": [ 7, 8 ], "name": "Estibaliz Lazaro", "orcid": "0000-0002-4206-7399" }, { "affs": [ 9 ], "name": "Tiphaine Goulenok", "orcid": "0000-0003-3680-6682" }, { "affs": [ 10 ], "name": "Alban Deroux" }, { "affs": [ 11 ], "name": "Alice Berezne" }, { "affs": [ 12 ], "name": "Loic Raffray" }, { "affs": [ 11 ], "name": "Chafika Morati-Hafsaoui" }, { "affs": [ 13 ], "name": "Christophe Richez" }, { "affs": [ 14 ], "name": "Eric Hachulla", "orcid": "0000-0001-7432-847X" }, { "affs": [ 15 ], "name": "Julien Campagne" }, { "affs": [ 16 ], "name": "Nicolas Schleinitz" }, { "affs": [ 17 ], "name": "Olivier Moranne" }, { "affs": [ 18 ], "name": "Vincent Langlois" }, { "affs": [ 19 ], "name": "Odile Debouverie" }, { "affs": [ 20 ], "name": "Francoise Sarrot-Reynauld" }, { "affs": [ 21 ], "name": "Viviane Queyrel" }, { "affs": [ 22 ], "name": "Pauline Orquevaux" }, { "affs": [ 23 ], "name": "Laurent Sailler" }, { "affs": [ 24 ], "name": "Maddalena Larosa" }, { "affs": [ 3 ], "name": "Anna Molto" }, { "affs": [ 25 ], "name": "Véronique Le Guern" }, { "affs": [ 26 ], "name": "Loïc Sentilhes" }, { "affs": [ 27 ], "name": "Nathalie Costedoat-Chalumeau", "orcid": "0000-0002-1555-9021" }, { "name": "Abisror Noemie" } ], "bibtex": "https://research.draconitic.com/paper/0tfaa77bhyszd.bib", "cited_by": 0, "doi": "10.1136/lupus-2026-002300", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735357/", "id": "0tfaa77bhyszd", "issns": [ "2053-8790" ], "landing_url": "https://doi.org/10.1136/lupus-2026-002300", "language": "en", "licence": "CC-BY-NC-4.0", "licence_label": "CC BY-NC 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "1506" ], [ "heading", "2257" ], [ "heading", "Epidemiology and Outcomes" ], [ "heading", "Original Research" ], [ "openalex", "2745|Systemic Lupus Erythematosus Research" ] ], "openalex": "W7225236502", "pdf_url": "https://lupus.bmj.com/content/13/2/e002300.full.pdf", "pmcid": "PMC13735357", "pmid": "42977479", "published": "2026-11-03", "publisher": "BMJ Publishing Group", "ris": "https://research.draconitic.com/paper/0tfaa77bhyszd.ris", "sources": [ { "first_seen": "2026-11-09T12:21:03Z", "native_id": "PMC13735357", "source": "pmc", "url": "https://doi.org/10.1136/lupus-2026-002300" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2745|Systemic Lupus Erythematosus Research", "subfield": "general" } ], "title": "Maternal and neonatal outcomes in SLE: comparison of 430 pregnancies from the French GR2 study with 1720 pregnancies from French perinatal surveys", "title_text": "Maternal and neonatal outcomes in SLE: comparison of 430 pregnancies from the French GR2 study with 1720 pregnancies from French perinatal surveys", "type": "peer-reviewed", "updated_at": "2026-11-09T12:21:03Z", "url": "https://research.draconitic.com/paper/0tfaa77bhyszd", "venue": "Lupus Science & Medicine", "versions": [] }