{
  "abstract": "Purpose\n\nTo evaluate the therapeutic potential of a suppressor of cytokine signaling 1 (SOCS1) mimetic peptide (MiS1) via systemic administration in a mouse model of diabetic retinopathy (DR).Methods\n\nMale db/db mice, a model of type 2 diabetes, were treated for 7 weeks with intraperitoneal injections of MiS1. In comparison, a group of animals received the Janus kinase (JAK)1/2 inhibitor baricitinib. Untreated diabetic db/db mice and non-diabetic db/m littermates served as controls. Retinal structure was assessed in vivo by optical coherence tomography. Retinal ganglion cell (RGC) survival (Brn3a+ cells) and Iba1-positive microglial activation (Iba1+ cells) were analyzed by immunohistochemistry in retinal wholemounts.Results\n\nUntreated db/db mice exhibited retinal thinning, RGC loss, and marked Iba1+ microglial activation. Both MiS1 and baricitinib treatments significantly attenuated retinal thinning, with MiS1 preserving retinal thickness at levels comparable to those of nondiabetic controls. RGC numbers were partially preserved in both treated groups, although the increase compared with untreated db/db mice reached statistical significance only in baricitinib-treated animals. Both treatments improved microglial morphology, mainly by increasing arbor area, whereas their effects on Iba1+ cell numbers were layer and parameter dependent.Conclusions\n\nSystemic administration of the SOCS1 mimetic peptide MiS1 showed a consistent protective profile on retinal thickness preservation and microglial remodeling in experimental DR. These findings support SOCS1-based therapies as a promising therapeutic strategy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Immunology, Ophthalmology, and ENT, Ramón Castroviejo Institute for Ophthalmic Research, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain.",
    "Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain.",
    "Renal, Vascular and Diabetes Research Laboratory IIS-Fundación Jiménez Díaz, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Universidad Autonoma de Madrid, Madrid, Spain.",
    "Health Science Faculty, University of Las Américas, Concepcion-Talcahuano, Chile.",
    "Department of Ophthalmology, University Hospital Fundación Jiménez Díaz, Madrid, Spain.",
    "Department of Cell Biology, Physiology and Immunology, Maimónides Biomedical Research Institute of Cordoba, UGC Nephrology, Hospital Universitario Reina Sofía, University of Córdoba, Córdoba, Spain."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Elena Salobrar-García"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Lucas Opazo-Ríos"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "José A Matamoros"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lidia Sánchez-Puebla"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "José A Fernández-Albarral"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Juan J Salazar"
    },
    {
      "affs": [
        4
      ],
      "name": "Raquel Castro"
    },
    {
      "affs": [
        2
      ],
      "name": "Manuel Soto-Catalán"
    },
    {
      "affs": [
        5
      ],
      "name": "Juan Antonio Moreno"
    },
    {
      "affs": [
        2
      ],
      "name": "Carmen Gómez-Guerrero"
    },
    {
      "affs": [
        2
      ],
      "name": "Sebastián Mas"
    },
    {
      "affs": [
        2
      ],
      "name": "Jesús Egido"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ana I Ramírez"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0tfm47mn80cz9.bib",
  "cited_by": 0,
  "doi": "10.1167/iovs.67.12.21",
  "fulltext_url": "https://europepmc.org/articles/PMC13676220",
  "id": "0tfm47mn80cz9",
  "issns": [
    "0146-0404",
    "1552-5783"
  ],
  "landing_url": "https://europepmc.org/article/MED/42872951",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Retinal Diseases and Treatments"
    ]
  ],
  "openalex": "W7221787682",
  "pdf_url": "https://europepmc.org/articles/PMC13676220?pdf=render",
  "pmcid": "PMC13676220",
  "pmid": "42872951",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0tfm47mn80cz9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42872951",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42872951"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Retinal Diseases and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Neuroprotective and Anti-Inflammatory Effects of SOCS1 Mimetic Peptides in Mouse Diabetic Retinopathy.",
  "title_text": "Neuroprotective and Anti-Inflammatory Effects of SOCS1 Mimetic Peptides in Mouse Diabetic Retinopathy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/0tfm47mn80cz9",
  "venue": "Investigative ophthalmology & visual science",
  "versions": []
}