{
  "abstract": "Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. Longitudinal studies are needed to link molecular and structural changes to vascular mechanics, hemodynamics, and tissue perfusion.\n\nMolecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. This Perspective argues for longitudinal studies to link molecular and structural changes to vascular mechanics, hemodynamics and tissue perfusion.",
  "abstract_shown": true,
  "affiliations": [
    "Biomedical Center, Metabolic Biochemistry, LMU Medizin, LMU Munich, Munich, Germany.",
    "Neuroimmunology and Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.",
    "Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.",
    "Munich Cluster for Systems Neurology (SyNergy), Munich, Germany."
  ],
  "article_type": "Perspective",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Thomas S Lewis"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jessica Wagner",
      "orcid": "0009-0004-8585-6998"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Jonas J Neher",
      "orcid": "0000-0003-1346-8924"
    }
  ],
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  "cited_by": 0,
  "doi": "10.1371/journal.pbio.3004051",
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  "licence_label": "CC BY",
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  "native_subjects": [
    [
      "heading",
      "Alzheimer's Disease"
    ],
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      "heading",
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    ],
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      "heading",
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      "heading",
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      "heading",
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      "heading",
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      "Body Fluids"
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      "heading",
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    ],
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      "Cellular Structures and Organelles"
    ],
    [
      "heading",
      "Dementia"
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    [
      "heading",
      "Diagnostic Medicine"
    ],
    [
      "heading",
      "Diagnostic Radiology"
    ],
    [
      "heading",
      "Extracellular Matrix"
    ],
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      "heading",
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      "heading",
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      "openalex",
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      "/Medicine and health sciences/Vascular medicine/Vascular permeability"
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  "pdf_url": "https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3004051&type=printable",
  "pmcid": "PMC13716199",
  "pmid": "42949878",
  "published": "2026-10-28",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/0vhc423kxskzt.ris",
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Biochemistry",
      "subfield": "general"
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    {
      "field": "biology",
      "origin": "heading:Cell Biology",
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  "title": "Alzheimer’s disease research must connect vascular molecular phenotypes with physiology",
  "title_text": "Alzheimer’s disease research must connect vascular molecular phenotypes with physiology",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:15Z",
  "url": "https://research.draconitic.com/paper/0vhc423kxskzt",
  "venue": "PLOS Biology",
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}