{
  "abstract": "Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used to treat obesity. However, their mechanism of action on adipose tissues remains incompletely understood. Methods: We exploited advanced three-dimensional imaging to investigate the effects of GLP-1RAs on sympathetic innervation in mouse adipose tissues. Results: Semaglutide or tirzepatide robustly promotes sympathetic innervation in inguinal white adipose tissue (iWAT) and interscapular brown adipose tissue (iBAT) but not in the liver tissues of mice with high-fat diet (HFD)-induced obesity. In addition, the sympathetic-promoting effect of tirzepatide occurs in the iWAT and iBAT of aged mice. Conversely, pharmacological ablation of sympathetic inputs results in alterations in adipocyte morphology and metabolic markers in GLP-1RA-treated HFD-fed mice. Moreover, GLP-1R is detected in neurons in the paraventricular nucleus of the hypothalamus of mice, a key brain region that elicits peripheral sympathetic signals, and semaglutide can effectively activate those neurons. Conclusions: These results provide new insights into the potential involvement of sympathetic action in adipose response to GLP-1RA treatment.",
  "abstract_shown": true,
  "affiliations": [
    "School of Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University Third Hospital, Peking University, Beijing 100871, China",
    "Peking Union Medical College Hospital, Beijing 100730, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Koukou Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhangyuzi Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjing Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jing Yang",
      "orcid": "0000-0002-2048-735X"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Cao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0vt1csfwh6y25.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16110813",
  "fulltext_url": null,
  "id": "0vt1csfwh6y25",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/11/813",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Adipose Tissue and Metabolism"
    ]
  ],
  "openalex": "W7223830414",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/0vt1csfwh6y25.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "10.3390/metabo16110813",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/11/813"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Adipose Tissue and Metabolism",
      "subfield": "physiology"
    }
  ],
  "title": "Glucagon-like Peptide-1 Receptor Agonists Promote Sympathetic Innervation in Mouse Adipose Tissues",
  "title_text": "Glucagon-like Peptide-1 Receptor Agonists Promote Sympathetic Innervation in Mouse Adipose Tissues",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/0vt1csfwh6y25",
  "venue": "Metabolites",
  "versions": []
}