{
  "abstract": "Lavandula angustifolia (lavender) extract displayed antioxidant properties in mammalian studies and has been promoted as a candidate neurotherapeutic for Alzheimer's disease (AD). To better inform its clinical utility, we exposed wildtype (N2) and spr-4 mutant strains of C. elegans to extracts from this lavender species and examined animals for neurobehavioral changes in a mechanosensory phenotype. Importantly, spr-4 encodes the worm ortholog of repressor element 1-silencing transcription factor (REST), an established genetic modifier of AD. While low concentrations of lavender did not alter behavioral responses, spr-4 mutants selectively displayed neuronal vulnerability at the highest concentration tested, thereby revealing dose-responsive, lavender-associated neurotoxicity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, United States"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Melissa L. Schlein"
    },
    {
      "affs": [
        0
      ],
      "name": "Cayman A. Stephen"
    },
    {
      "affs": [
        0
      ],
      "name": "Guy A. Caldwell"
    },
    {
      "affs": [
        0
      ],
      "name": "Lukasz Ciesla"
    },
    {
      "affs": [
        0
      ],
      "name": "Kim A. Caldwell"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0vw6qrv4jsp5h.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002220",
  "fulltext_url": "https://www.micropublication.org/journals/biology/micropub-biology-002220",
  "id": "0vw6qrv4jsp5h",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://doi.org/10.17912/micropub.biology.002220",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7165478974",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": "Caltech Library",
  "ris": "https://research.draconitic.com/paper/0vw6qrv4jsp5h.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T14:21:02Z",
      "native_id": "0f16adf1d635455e8df92a99c95de043",
      "source": "doaj",
      "url": "https://doi.org/10.17912/micropub.biology.002220"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "An Alzheimer’s disease-associated mutant of C. elegans displays mechanosensory sensitivity following exposure to lavender extracts",
  "title_text": "An Alzheimer’s disease-associated mutant of C. elegans displays mechanosensory sensitivity following exposure to lavender extracts",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T14:20:16Z",
  "url": "https://research.draconitic.com/paper/0vw6qrv4jsp5h",
  "venue": "microPublication Biology",
  "versions": []
}