{
  "abstract": "The synthesis of tertiary fluoride-containing stereogenic centers remains a significant challenge. This challenge is amplified when such units are embedded within vicinal stereocenters arrays, where both absolute and relative stereochemistry must be controlled. Here we disclose a stereodivergent Lewis base-iridium cooperative catalysis method that unites α-fluorinated C1-ammonium enolate and π(allyl)Ir intermediates to construct tertiary fluoride-containing stereodiads. Each catalyst is independently responsible for the configurational outcome of each stereocenter comprising the stereodiad during Csp³-Csp³ bond construction. The conversion of easily prepared racemic α-fluoro esters to single α-fluoro C1-ammonium enolates via Lewis base catalysis is noteworthy.",
  "abstract_shown": true,
  "affiliations": [
    "Indiana University, Department of Chemistry 800 E. Kirkwood Ave. Bloomington IN 47405 USA tsnaddon@iu.edu https://snaddon.lab.indiana.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Smita Mandal"
    },
    {
      "affs": [
        0
      ],
      "name": "Maren Pink"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas N Snaddon",
      "orcid": "0000-0003-1119-0332"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0wdfechpey8jw.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc06429a",
  "fulltext_url": "https://europepmc.org/articles/PMC13684430",
  "id": "0wdfechpey8jw",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909855",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7161553069",
  "pdf_url": "https://europepmc.org/articles/PMC13684430?pdf=render",
  "pmcid": "PMC13684430",
  "pmid": "42909855",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0wdfechpey8jw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909855",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909855"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Stereodivergent Csp³-Csp³ bond construction via Lewis base/iridium cooperative catalysis: a modular synthesis of tertiary fluoride-containing stereodiads.",
  "title_text": "Stereodivergent Csp³-Csp³ bond construction via Lewis base/iridium cooperative catalysis: a modular synthesis of tertiary fluoride-containing stereodiads.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/0wdfechpey8jw",
  "venue": "Chemical science",
  "versions": []
}