{
  "abstract": "Aim: To assess the relationship between baseline coagulation parameters and 90-day neurological functional status in patients with acute ischaemic stroke (AIS) undergone intravenous recombinant tissue plasminogen activator (rt-PA) thrombolysis.\n\nMethods: We implemented a retrospective cohort study of 200 AIS patients who underwent intravenous rt-PA thrombolysis from January 2024 to December 2025. Baseline coagulation parameters were measured before thrombolysis. The primary outcome was poor functional outcome [modified Rankin Scale (mRS) score 3–6 at 90 days]. Multivariable logistic regression was used to estimate adjusted associations between baseline variables and 90-day outcome. A four-marker logistic model was explored, and receiver operating characteristic (ROC) analysis was used to describe its apparent discrimination within the study cohort.\n\nResults: Of the 200 enrolled patients, poor 90-day functional status was seen in 68 (34.0%). The baseline D-dimer (2.18 ± 1.64 vs. 0.87 ± 0.65 mg/L, P < 0.001), fibrinogen (3.82 ± 0.91 vs. 3.15 ± 0.76 g/L, P < 0.001), PT (12.84 ± 1.12 vs. 12.15 ± 0.89 s, P < 0.001) and APTT (32.56 ± 3.42 vs. 29.87 ± 2.65 s, P < 0.001) levels were higher in the poor outcome group than the favourable outcome group. In multivariable analysis, elevated D-dimer (OR = 2.143, 95% CI = 1.452–3.162, P < 0.001), increased fibrinogen (OR = 1.876, 95% CI = 1.123–3.134, P = 0.016) and prolonged APTT (OR = 1.215, 95% CI = 1.032–1.431, P = 0.019) remained associated with poor 90-day functional status after adjustment for the measured covariates included in the model. The four-coagulation-marker model had an apparent AUC of 0.812 (95% CI = 0.735–0.888) in the same cohort.\n\nConclusion: Baseline D-dimer, fibrinogen and APTT were associated with 90-day neurological functional status among AIS patients treated with intravenous rt-PA. These markers should not be interpreted as stand-alone predictors of outcome; their incremental prognostic value beyond established clinical factors and their clinical utility require prospective external validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Beijing Shunyi Hospital, Beijing, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jing Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Quping Ouyang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0wwe5sa84gmw5.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1965269",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731398/",
  "id": "0wwe5sa84gmw5",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.1965269",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2728|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7223091892",
  "pdf_url": "https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1965269/pdf",
  "pmcid": "PMC13731398",
  "pmid": "42985183",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/0wwe5sa84gmw5.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:36Z",
      "native_id": "PMC13731398",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1965269"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Acute Ischemic Stroke Management",
      "subfield": "neurology"
    }
  ],
  "title": "Relationship between coagulation function indicators and neurological outcome following rt-PA thrombolysis in acute ischaemic stroke",
  "title_text": "Relationship between coagulation function indicators and neurological outcome following rt-PA thrombolysis in acute ischaemic stroke",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:36Z",
  "url": "https://research.draconitic.com/paper/0wwe5sa84gmw5",
  "venue": "Frontiers in Medicine",
  "versions": []
}