{
  "abstract": "This study reports the development of a biodegradable poly(lactic acid) and gelatin (nPLA-G) bionanocomposite as a drug delivery system for chloroaluminum phthalocyanine (ClAlPc) in photodynamic therapy (PDT). Using a hybrid desolvation/emulsification technique, we engineered spherical nanoparticles with an average diameter of 753.3 nm and a positive zeta potential of +8.90 mV. ClAlPc-loaded nanoparticles (nPLA-G/ClAlPc) were prepared using the same process, with a mean diameter of 809.3 nm and a zeta potential of +16.10 mV. The system achieved an exceptional encapsulation efficiency of 90.89% and maintained colloidal stability for over 270 days. In vitro assays showed a pH-dependent release profile, optimizing drug availability in tumoral microenvironments. The nPLA-G/ClAlPc system showed no dark toxicity but reached 97% cytotoxicity in SK-MEL-28 melanoma cells upon light activation (1.0 μmol L–1). These preliminary results demonstrate that the bionanocomposite effectively overcomes ClAlPc hydrophobicity, serving as a promising drug delivery system with preliminary photodynamic efficacy in vitro.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade do Vale do Paraíba , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Janicy A. Carvalho",
      "orcid": "0000-0003-4376-7888"
    },
    {
      "affs": [
        0
      ],
      "name": "Jéssica A. R. Ambrósio"
    },
    {
      "affs": [
        0
      ],
      "name": "Milton Beltrame Junior"
    },
    {
      "affs": [
        0
      ],
      "name": "Vitor L. M. Marmo"
    },
    {
      "affs": [
        0
      ],
      "name": "Leandro J. Raniero"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucas F. Lyra"
    },
    {
      "affs": [
        0
      ],
      "name": "Kumiko K. Sakane"
    },
    {
      "affs": [
        0
      ],
      "name": "Juliana G. Pinto"
    },
    {
      "affs": [
        0
      ],
      "name": "Tassia J. Martins"
    },
    {
      "affs": [
        0
      ],
      "name": "Juliana Ferreira-Strixino"
    },
    {
      "affs": [
        0
      ],
      "name": "Andreza R. Simioni",
      "orcid": "0000-0002-3087-7431"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0wxv882336acw.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05499",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718232/?tool=EBI",
  "id": "0wxv882336acw",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/42/64825/5450451/Highly-Stable-PLA-Gelatin-Bionanocomposites-for",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2740|Photodynamic Therapy Research Studies"
    ]
  ],
  "openalex": "W7221701863",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c05499",
  "pmcid": "PMC13718232",
  "pmid": "42960078",
  "published": "2026-10-13",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0wxv882336acw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c05499",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/42/64825/5450451/Highly-Stable-PLA-Gelatin-Bionanocomposites-for"
    },
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13718232",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718232"
    },
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42960078",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960078"
    },
    {
      "first_seen": "2026-11-02T12:22:19Z",
      "native_id": "PMC13718232",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acsomega.6c05499"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Photodynamic Therapy Research Studies",
      "subfield": "general"
    }
  ],
  "title": "Highly Stable PLA/Gelatin Bionanocomposites for Enhanced Delivery of Chloroaluminum Phthalocyanine for Photodynamic Therapy against SK-MEL-28 Cells",
  "title_text": "Highly Stable PLA/Gelatin Bionanocomposites for Enhanced Delivery of Chloroaluminum Phthalocyanine for Photodynamic Therapy against SK-MEL-28 Cells",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:19Z",
  "url": "https://research.draconitic.com/paper/0wxv882336acw",
  "venue": "ACS Omega",
  "versions": []
}