{
  "abstract": "Background: Helicobacter pylori (H. pylori) infection has been linked to several extragastric metabolic disorders. However, its cross-sectional association with hyperuricemia remains uncertain, partly because previous studies have often been limited by small sample sizes and incomplete adjustment for metabolic and renal factors. Methods: This large-scale cross-sectional study used data from a health examination database. The main regression analyses included 67,826 participants with valid H. pylori status, serum uric acid measurements, hyperuricemia classification, age, sex, and BMI. Modified Poisson regression with a log link and HC0 robust sandwich variance was used to estimate prevalence ratios for hyperuricemia, while linear regression with HC3 heteroscedasticity-robust standard errors was used for continuous serum uric acid. Sex-stratified and robustness analyses were also performed. Results: In the unadjusted model, H. pylori infection was associated with higher prevalence of hyperuricemia (PR = 1.27, 95% CI: 1.22–1.32, p < 0.001). This association was progressively attenuated after sequential adjustment and was small in the extended clinical model (PR = 1.02, 95% CI: 0.98–1.06, p = 0.269). For continuous serum uric acid, H. pylori positivity remained associated with a small increase after full adjustment (β = 2.14 μmol/L, 95% CI: 0.80–3.49, p = 0.002). Functional-form sensitivity analyses yielded similarly small effect estimates for hyperuricemia, although statistical significance varied across model specifications. Sex-stratified and robustness analyses were generally consistent with these findings. Conclusion: In this large health examination population, any remaining association between H. pylori positivity and hyperuricemia after comprehensive adjustment was small and sensitive to model specification. H. pylori positivity was also associated with a statistically detectable but clinically modest difference in continuous serum uric acid levels. Given the cross-sectional design, these findings should not be interpreted causally.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nursing, Shanghai Health and Medical Center, Wuxi, Jiangsu Province, China",
    "Department of Diagnostic Imaging, Shanghai Health and Medical Center, Wuxi, Jiangsu Province, China",
    "Department of Clinical Laboratory, Shanghai Health and Medical Center, Wuxi, Jiangsu Province, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhiyue Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiuyu Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Jie Huang"
    },
    {
      "name": "Chunxing Liu"
    },
    {
      "name": "Yong Fang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0x61ygr1y7jrm.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0358039",
  "fulltext_url": null,
  "id": "0x61ygr1y7jrm",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0358039",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Gout, Hyperuricemia, Uric Acid"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Body fluids/Blood/Blood sugar"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Renal system"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Biomarkers/Creatinine"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Metabolism/Carbohydrate metabolism/Glucose metabolism"
    ],
    [
      "plos",
      "/Biology and life sciences/Immunology/Immune response/Inflammation"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Body fluids/Blood/Blood sugar"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Endocrine physiology/Insulin resistance"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Body fluids/Blood/Blood sugar"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Renal system"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Endocrinology/Endocrine physiology/Insulin resistance"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune response/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Vascular medicine/Blood pressure"
    ],
    [
      "plos",
      "/Physical sciences/Chemistry/Chemical compounds/Acids/Uric acid"
    ]
  ],
  "openalex": "W7202115820",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0358039&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/0x61ygr1y7jrm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pone.0358039",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0358039"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
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  "title": "Helicobacter pylori infection, hyperuricemia, and serum uric acid levels: The role of metabolic, renal, and inflammatory factors in a large health examination population",
  "title_text": "Helicobacter pylori infection, hyperuricemia, and serum uric acid levels: The role of metabolic, renal, and inflammatory factors in a large health examination population",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/0x61ygr1y7jrm",
  "venue": "PLOS One",
  "versions": []
}