{
  "abstract": "Female reproductive diseases (FRDs) substantially affect women’s health and fertility, with lipid metabolic reprogramming emerging as a shared pathological feature. Long-chain acyl-CoA synthetases (ACSLs) activate long-chain fatty acids and direct lipid flux toward β-oxidation, lipid synthesis, and phospholipid remodeling, thereby influencing oxidative stress, ferroptosis, and inflammatory signaling. Unlike previous reviews centered on broad ACSL biology, selected isoforms, or pathway-based ferroptosis mechanisms, this review adopts a disease-spanning, isoform-specific framework. We compare ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6 across cervical, ovarian, and endometrial cancers, polycystic ovary syndrome, endometriosis, and preeclampsia. By integrating isoform-specific substrate preference, subcellular localization, and lipid-channeling functions, we examine how individual ACSLs differentially regulate fatty acid oxidation, lipid synthesis and phospholipid remodeling, ferroptosis sensitivity, and inflammatory signaling across reproductive disease contexts. We further distinguish disease-specific experimental evidence from bioinformatic associations and mechanistic extrapolations from other disease models. Current evidence most consistently supports a disease-relevant role for ACSL4 in ferroptosis regulation, whereas ACSL1, ACSL3, ACSL5, and ACSL6 show greater context dependence. This integrated framework identifies shared metabolic mechanisms, disease-specific differences, and priorities for cell-resolved validation and future isoform-selective therapeutic development.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University",
    "Advanced Institute for Medical Sciences, Dalian Medical University",
    "Department of Otorhinolaryngology, the Second Hospital of Dalian Medical University",
    "School of Basic Medical Sciences, Dalian University of Technology"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shanyuan Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Lin Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Zishuo Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zirong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Runyuan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Kong"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Hongshuo Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0x6cadt958w2c.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1967984",
  "fulltext_url": null,
  "id": "0x6cadt958w2c",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1967984/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Cancer, Lipids, and Metabolism"
    ]
  ],
  "openalex": "W7224106246",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/0x6cadt958w2c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1967984",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1967984/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer, Lipids, and Metabolism",
      "subfield": "oncology"
    }
  ],
  "title": "Long-chain acyl-CoA synthetases in female reproductive diseases: isoform-specific regulation of lipid metabolism, ferroptosis, and inflammatory signaling",
  "title_text": "Long-chain acyl-CoA synthetases in female reproductive diseases: isoform-specific regulation of lipid metabolism, ferroptosis, and inflammatory signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:20Z",
  "url": "https://research.draconitic.com/paper/0x6cadt958w2c",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}