{
  "abstract": "Rapid DNA transport limits the temporal resolution of solid-state nanopore sensing. Here we show that breaking pore symmetry through geometric inclination produces exceptionally prolonged DNA residence without surface functionalization or external trapping. For 500-base-pair double-stranded (ds) DNA ,13 nm diameter SiNx pores in tilted membranes exhibit a distinct long-lived population with a mean dwell time of 11.1 seconds at 600 mV bias, exceeding previously reported dsDNA dwell times by at-least 4 orders of magnitude. Controlled pore tilting reproduces the population of prolonged events, whose prevalence and duration depend on ionic strength. TEM-EELS based thickness measurements exclude substantial membrane-thickness differences, while continuum and atomistic simulations support a mechanism coupling electric-field redistribution to off-axis DNA motion, increased pore-wall contact and suppressed axial mobility. These findings establish geometric inclination as a passive design variable for engineering molecular residence in solid-state nanopores and provide a route towards longer observation windows for single-molecule sensing.",
  "abstract_shown": true,
  "affiliations": [
    "Indian Institute of Science"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "S. Nasa"
    },
    {
      "name": "P. Sur"
    },
    {
      "name": "P. K. Maiti"
    },
    {
      "affs": [
        0
      ],
      "name": "M. Varma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0xwh3hk76kb6c.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.20.753066",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.20.753066v1.full",
  "id": "0xwh3hk76kb6c",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.20.753066v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioengineering"
    ],
    [
      "openalex",
      "2204|Nanopore and Nanochannel Transport Studies"
    ]
  ],
  "openalex": "W7213986335",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.20.753066v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0xwh3hk76kb6c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:40Z",
      "native_id": "10.64898/2026.09.20.753066",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.20.753066v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioengineering",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Breaking Pore Symmetry to Prolong DNA Residence in Solid-State Nanopores",
  "title_text": "Breaking Pore Symmetry to Prolong DNA Residence in Solid-State Nanopores",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:40Z",
  "url": "https://research.draconitic.com/paper/0xwh3hk76kb6c",
  "venue": "bioRxiv",
  "versions": []
}