{
  "abstract": "Cortical circuits require precise inhibitory and excitatory neurotransmission to encode information and prevent pathology. Metabotropic GABAB receptors (GABABRs) are key inhibitory regulators in mammalian neurons. In GABAergic interneurons (INs), GABABR activation reduces inhibition, leading to disinhibitory mechanisms. Hippocampal somatostatin-expressing (SST) INs provide feedback inhibition to distal dendrites of principal cells (PCs) and other INs. Plasticity of SST INs is well established to control hippocampal circuit function dependent on metabotropic glutamate receptors (mGluRs) and GABABRs. Whether GABABRs regulate SST INs function over longer time scales and if this influences circuit function remains unclear.\n\nWe combine quantitative freeze-fracture replica immunoelectron microscopy, ex vivo electrophysiology, and pharmacology to show that GABABR activation regulates long-term potentiation (LTP) of SST INs through protein phosphatase 2A (PP2A)-dependent loss of cell-surface GABABR, mGluR1α receptors, and Cav1.2 (L-type) Ca2+ channels. GABABR loss in SST INs shifts hippocampal activity toward greater plasticity of long-range inputs to CA1.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Nithya Sethumadhavan"
    },
    {
      "name": "Max A. Wilson"
    },
    {
      "name": "Anna Sumera"
    },
    {
      "name": "Desiree Loreth"
    },
    {
      "name": "Rita M. Loureiro"
    },
    {
      "name": "Imre Vida"
    },
    {
      "name": "Akos Kulik"
    },
    {
      "name": "Sam A. Booker",
      "orcid": "0000-0003-1980-9873"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0y0e4d2g33yxd.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117878",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733333/",
  "id": "0y0e4d2g33yxd",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03261-X",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Cell biology"
    ],
    [
      "heading",
      "Cellular neuroscience"
    ],
    [
      "heading",
      "Molecular network"
    ],
    [
      "heading",
      "Sensory neuroscience"
    ],
    [
      "openalex",
      "2804|Neuroscience and Neuropharmacology Research"
    ]
  ],
  "openalex": "W7223984641",
  "pdf_url": null,
  "pmcid": "PMC13733333",
  "pmid": "42985523",
  "published": "2026-10-27",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/0y0e4d2g33yxd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117878",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03261-X"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117878",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S258900422603261X"
    },
    {
      "first_seen": "2026-11-08T12:23:08Z",
      "native_id": "PMC13733333",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117878"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "PP2A-dependent downregulation of GABAB receptors modulates somatostatin interneurons function and plasticity",
  "title_text": "PP2A-dependent downregulation of GABAB receptors modulates somatostatin interneurons function and plasticity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:08Z",
  "url": "https://research.draconitic.com/paper/0y0e4d2g33yxd",
  "venue": "iScience",
  "versions": []
}