{
  "abstract": "The field of Alzheimer's disease (AD) research has seen major advances in understanding manifestations of AD‐related neuropsychiatric symptoms (NPS), including recent addition of NPS to the 2024 National Institute of Aging–Alzheimer's Association (NIA‐AA) clinical staging framework. This focused review highlights key publications (49 in 2024; 28 in 2025) indexed in MEDLINE examining AD‐related NPS, in alignment with the Scale for the Assessment of Narrative Review Articles guidelines. Data were thematically organized across NIA‐AA clinical stages, with emphasis on measurement, diagnosis, and biomarker‐cognition correlates of AD‐related NPS. Together, these findings can inform future research and clinical practice through enhanced understanding of AD‐related NPS and their relationships with pathology and clinical outcomes. Finally, three key priorities were identified for future research: (1) incorporating sex/gender and ethnocultural diversity; (2) integrating NPS assessment with cognitive, fluid, and neuroimaging biomarkers; and (3) including perspectives of individuals with lived experience to support personalized NPS management.",
  "abstract_shown": true,
  "affiliations": [
    "Sunnybrook Research Institute Toronto Ontario Canada",
    "Department of Pharmacology and Toxicology University of Toronto Toronto Ontario Canada",
    "Faculty of Graduate Studies University of Calgary Calgary Alberta Canada",
    "Hotchkiss Brain Institute Cumming School of Medicine University of Calgary Calgary Alberta Canada",
    "Department of Psychology Brunel University of London Uxbridge, London UK",
    "Department of Psychiatry Cumming School of Medicine University of Calgary Calgary Alberta Canada",
    "Centre for Addiction and Mental Health Toronto Ontario Canada",
    "Department of Psychiatry University of Toronto Toronto Ontario Canada",
    "Mortby Consulting Canberra Australian Capital Territory Australia",
    "University of New South Wales Sydney New South Wales Australia",
    "UNSW Ageing Futures Institute Sydney New South Wales Australia",
    "Neuroscience Research Australia Sydney New South Wales Australia",
    "Escola Paulista de Medicina Federal University of São Paulo (UNIFESP) São Paulo São Paulo Brazil",
    "Department of Psychiatry Faculty of Medicine University of Southampton Southampton UK",
    "Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA",
    "McLean Hospital Belmont Massachusetts USA",
    "Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Krushnaa Sankhe",
      "orcid": "0000-0003-0535-4935"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Daniella Vellone"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Dylan X. Guan"
    },
    {
      "affs": [
        4
      ],
      "name": "Byron Creese"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Zahinoor Ismail"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Sanjeev Kumar"
    },
    {
      "affs": [
        0,
        1,
        7
      ],
      "name": "Krista L. Lanctôt"
    },
    {
      "affs": [
        8,
        9,
        10,
        11
      ],
      "name": "Moyra E. Mortby"
    },
    {
      "affs": [
        12
      ],
      "name": "Fabricio Ferreira de Oliveira"
    },
    {
      "affs": [
        13
      ],
      "name": "Lindsey Sinclair"
    },
    {
      "affs": [
        14,
        15
      ],
      "name": "Jennifer Gatchel"
    },
    {
      "affs": [
        14,
        16
      ],
      "name": "Catherine E. Munro",
      "orcid": "0000-0002-8707-1826"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0y860m058bxcr.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70510",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13728318/",
  "id": "0y860m058bxcr",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://doi.org/10.1002/dad2.70510",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7225145823",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70510",
  "pmcid": "PMC13728318",
  "pmid": "42978812",
  "published": "2026-11-02",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/0y860m058bxcr.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:24:01Z",
      "native_id": "PMC13728318",
      "source": "pmc",
      "url": "https://doi.org/10.1002/dad2.70510"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Neuropsychiatric symptoms across the revised Alzheimer's disease clinical staging framework: A review of current evidence and implications",
  "title_text": "Neuropsychiatric symptoms across the revised Alzheimer's disease clinical staging framework: A review of current evidence and implications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:20Z",
  "url": "https://research.draconitic.com/paper/0y860m058bxcr",
  "venue": "Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring",
  "versions": []
}