{
  "abstract": "Background\n\nMetabolic dysfunction-associated steatotic liver disease (MASLD) is linked to type 2 diabetes mellitus (T2D), with insulin resistance, dyslipidemia, and inflammation contributing to disease progression. Interferon-γ-inducible protein-10 (IP-10) is a proinflammatory chemokine implicated in hepatic inflammation and metabolic dysfunction.Objectives\n\nTo assess circulating IP-10 levels in patients with concomitant T2D and MASLD, examine their associations with metabolic and hepatic parameters, and evaluate their discriminatory performance.Methods\n\nThis case-control study included 120 adults (60 patients with T2D and MASLD, and 60 age- and sex-matched healthy controls). Hepatic steatosis and fibrosis were evaluated using ultrasonography, transient elastography (FibroScan®), hepatic steatosis index, and FIB-4 score. Serum IP-10 levels were measured using ELISA and its discriminatory performance was assessed using receiver operating characteristic (ROC) curve analysis.Results\n\nSerum IP-10 was significantly higher in patients with T2D and MASLD compared with controls. Serum IP-10 showed significant positive correlations with LDL-C, HbA1c, HOMA-IR, FIB-4 score, and liver stiffness measurements, while remaining unrelated to steatosis grade or BMI. ROC curve analysis demonstrated excellent discriminatory performance of IP-10 between patients with T2D and MASLD and metabolically healthy controls, with an AUC of 0.97 at a cut-off value >940 pg/mL, yielding 85.0% sensitivity and 96.7% specificity.Conclusion\n\nSerum IP-10 is significantly elevated in patients with MASLD and T2D and correlates with key markers of metabolic dysfunction and hepatic fibrosis. IP-10 demonstrates excellent discriminatory ability between patients with combined T2D and MASLD and metabolically healthy controls, supporting its potential relevance as a non-invasive biomarker in this metabolic phenotype.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology and Metabolism, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.",
    "Department of Hepatogastroenterology and Infectious Diseases, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.",
    "Department of Biochemistry and Molecular Biology, Faculty of Pharmacy for Boys, Al-Azhar University, Cairo, Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nahla Bashir"
    },
    {
      "affs": [
        0
      ],
      "name": "Olfat Fawzy"
    },
    {
      "affs": [
        0
      ],
      "name": "Sally Abd El-Aziz"
    },
    {
      "affs": [
        1
      ],
      "name": "Moshira A Ibrahim"
    },
    {
      "affs": [
        2
      ],
      "name": "Emad G Khidr"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0yprxjb74d2yh.bib",
  "cited_by": 0,
  "doi": "10.4103/sjmms.sjmms_438_26",
  "fulltext_url": "https://europepmc.org/articles/PMC13727055",
  "id": "0yprxjb74d2yh",
  "issns": [
    "1658-631X",
    "2321-4856"
  ],
  "landing_url": "https://europepmc.org/article/MED/42974313",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222613697",
  "pdf_url": "https://europepmc.org/articles/PMC13727055?pdf=render",
  "pmcid": "PMC13727055",
  "pmid": "42974313",
  "published": "2026-10-14",
  "publisher": "Wolters Kluwer -- Medknow Publications",
  "ris": "https://research.draconitic.com/paper/0yprxjb74d2yh.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42974313",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974313"
    },
    {
      "first_seen": "2026-11-05T12:23:15Z",
      "native_id": "PMC13727055",
      "source": "pmc",
      "url": "https://doi.org/10.4103/sjmms.sjmms_438_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Serum Interferon Gamma-induced Protein 10 Levels in Patients with Type 2 Diabetes and Metabolic Dysfunction-associated Steatotic Liver Disease: A Case-control Study.",
  "title_text": "Serum Interferon Gamma-induced Protein 10 Levels in Patients with Type 2 Diabetes and Metabolic Dysfunction-associated Steatotic Liver Disease: A Case-control Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:51Z",
  "url": "https://research.draconitic.com/paper/0yprxjb74d2yh",
  "venue": "Saudi journal of medicine & medical sciences",
  "versions": []
}