{
  "abstract": "Background. Six parasite–cancer associations are supported by IARC carcinogen classification or strong mechanistic and epidemiological evidence: Schistosoma haematobium → bladder cancer (Group 1); Opisthorchis viverrini and Clonorchis sinensis → cholangiocarcinoma (Group 1); Schistosoma japonicum → colorectal cancer (Group 2B, priority reclassification); Plasmodium falciparum → endemic Burkitt lymphoma (Group 2A, reclassification evidence reviewed in Study 8 ([10.5281/zenodo.20402639](https://doi.org/10.5281/zenodo.20402639))); and Strongyloides stercoralis × HTLV-1 → adult T-cell leukemia/lymphoma (mechanistic evidence reviewed in Study 9 ([10.5281/zenodo.20402641](https://doi.org/10.5281/zenodo.20402641))). These associations span five parasite taxa, four cancer types, and four continents. No synthesis has mapped their underlying mechanisms onto a common framework. Methods. Narrative mechanistic synthesis. PubMed and Google Scholar were searched for publications on: (1) parasite-induced inflammation and genotoxicity; (2) helminth-driven immune polarisation; (3) parasite extracellular vesicles and epigenetic reprogramming; (4) parasite–oncovirus amplification systems. Results are...",
  "abstract_shown": true,
  "affiliations": [
    "Independent Researcher"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marcus Webb"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0yyk3an75yq54.bib",
  "cited_by": 16,
  "doi": "10.5281/zenodo.20402672",
  "fulltext_url": null,
  "id": "0yyk3an75yq54",
  "issns": [],
  "landing_url": "https://doi.org/10.5281/zenodo.20402672",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2405|Parasites and Host Interactions"
    ]
  ],
  "openalex": "W7162459510",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-27",
  "publisher": "European Organization for Nuclear Research",
  "ris": "https://research.draconitic.com/paper/0yyk3an75yq54.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:51Z",
      "native_id": "W7162459510",
      "source": "openalex",
      "url": "https://doi.org/10.5281/zenodo.20402672"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2405|Parasites and Host Interactions",
      "subfield": "microbiology"
    }
  ],
  "title": "Closing the Mechanism Loop: A Unified Mechanistic Framework for Parasite-Associated Carcinogenesis",
  "title_text": "Closing the Mechanism Loop: A Unified Mechanistic Framework for Parasite-Associated Carcinogenesis",
  "type": "preprint",
  "updated_at": "2026-11-09T13:21:11Z",
  "url": "https://research.draconitic.com/paper/0yyk3an75yq54",
  "venue": "Zenodo (CERN European Organization for Nuclear Research)",
  "versions": []
}