{
  "abstract": "Introduction: Identifying the factors that influence attitudes toward biomedical research is essential for improving public engagement and participation. The COVID-19 pandemic offers a unique opportunity to assess how a public health crisis shapes perceptions of clinical research. We investigated whether attitudes toward biomedical research differed across phases of the COVID-19 pandemic.\n\nMethods: We analyzed data from 5,098 adults enrolled in the UC Irvine Consent-to-Contact (C2C) registry, an online voluntary recruitment registry in Southern California, between June 2016 and August 2025. Research attitudes were assessed with the validated 7-item Research Attitudes Questionnaire (RAQ) at enrollment and annually thereafter. Scores were analyzed continuously (7 -35) and dichotomously, with >28 defined a priori as high. COVID-19 periods were defined a priori as: P1 (before March 13, 2020—the U.S. national emergency declaration), P2 (March 13 to December 11, 2020—prior to COVID-19 vaccine approval), and P3 (after December 11, 2020—post-vaccine approval). Cross-sectional analyses included all participants; longitudinal analyses were limited to 1,388 participants who enrolled before March 2020 and had ≥3 assessments.\n\nResults: Our sample of 5,098 adults was predominantly non-Hispanic White (70.2%), female (65.7%), highly educated, and over age 50 (66.7%). Participants enrolling during P2 had 60% higher odds of a high RAQ score (>28) compared with P1 (aOR 1.60; 95% CI: 1.07, 2.40; p =0.022). Longitudinally, the mean within-subject RAQ score was significantly higher during P2 versus P1 (Est. 0.37; 95% CI: 0.08, 0.66; p =0.011), and the odds of a high RAQ score were 24% higher in P2 (aOR 1.24; 95% CI: 1.09, 1.39; p <0.001) compared to P1.\n\nDiscussion: These findings suggest that awareness of urgent medical issues, such as the COVID-19 pandemic, may affect attitudes toward research.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Statistics, University of California, Irvine",
    "Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine",
    "Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health",
    "Division of Geriatrics, Department of Medicine, University of Wisconsin School of Medicine and Public Health",
    "Department of Neurobiology and Behavior, University of California, Irvine",
    "Department of Psychiatry and Human Behavior, University of California, Irvine",
    "Institute for Clinical and Translational Science, University of California, Irvine"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sarah K. Schlund"
    },
    {
      "affs": [
        1
      ],
      "name": "Dan K. Hoang"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Amy J. H. Kind"
    },
    {
      "affs": [
        1,
        4,
        5,
        6
      ],
      "name": "Joshua D. Grill"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Daniel L. Gillen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0z2yewvre1edq.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1899763",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716716/?tool=EBI",
  "id": "0z2yewvre1edq",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1899763/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2739|Ethics in Clinical Research"
    ]
  ],
  "openalex": "W7222245116",
  "pdf_url": "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1899763/pdf",
  "pmcid": "PMC13716716",
  "pmid": "42959262",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/0z2yewvre1edq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.3389/fpubh.2026.1899763",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1899763/full"
    },
    {
      "first_seen": "2026-10-31T00:20:37Z",
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      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13716716"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
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      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959262"
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      "url": "https://doi.org/10.3389/fpubh.2026.1899763"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Ethics in Clinical Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Research attitudes through the COVID-19 pandemic",
  "title_text": "Research attitudes through the COVID-19 pandemic",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:10Z",
  "url": "https://research.draconitic.com/paper/0z2yewvre1edq",
  "venue": "Frontiers in Public Health",
  "versions": []
}