{
  "abstract": "Numerous long-standing questions in origins-of-life research center on the origin of today’s biopolymers. The dependence of biochemistry on metals appears to be ancient and rooted in chemical evolution. While the effect of metal ions on the abiotic polymerization of peptides and nucleic acids has been investigated, their effect on sugar oligomerization reactions has not been established. Here, we have performed drying reactions of glucose as a model saccharide in the presence or absence of various metal ions and characterized the resulting products using a variety of analytical techniques. We found that while metal ions typically inhibited the overall conversion of glucose into oligomers, some ions led to an apparent shift in oligomeric distribution, in a metal-specific manner. Our results are suggestive of metal-sugar co-evolution during the early stages of prebiotic evolution.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel",
    "The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, Israel",
    "Casali Center of Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Daniil Akulenko"
    },
    {
      "affs": [
        0
      ],
      "name": "Rotem Edri"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Moran Frenkel-Pinter",
      "orcid": "0000-0001-7235-5845"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0zzr0gdp5jfts.bib",
  "cited_by": 0,
  "doi": "10.1038/s42004-026-02129-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737047/",
  "id": "0zzr0gdp5jfts",
  "issns": [
    "2399-3669"
  ],
  "landing_url": "https://doi.org/10.1038/s42004-026-02129-w",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "3103|Origins and Evolution of Life"
    ]
  ],
  "openalex": "W7168127170",
  "pdf_url": "https://www.nature.com/articles/s42004-026-02129-w_reference.pdf",
  "pmcid": "PMC13737047",
  "pmid": "42443447",
  "published": "2026-07-13",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/0zzr0gdp5jfts.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:21Z",
      "native_id": "PMC13737047",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s42004-026-02129-w"
    }
  ],
  "subjects": [
    {
      "field": "astronomy",
      "origin": "openalex:3103|Origins and Evolution of Life",
      "subfield": "general"
    }
  ],
  "title": "Metal ions affect abiotic sugar oligomerization reactions",
  "title_text": "Metal ions affect abiotic sugar oligomerization reactions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:21Z",
  "url": "https://research.draconitic.com/paper/0zzr0gdp5jfts",
  "venue": "Communications Chemistry",
  "versions": []
}