{
  "abstract": "Aims\n\nWe aimed to investigate the role of glymphatic dysfunction in the association between stenosis and cognition.Methods\n\nOlder adults from a longitudinal cohort underwent magnetic resonance angiography to quantify cerebral artery stenosis burden. Glymphatic function was evaluated using diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) and free water in white matter (FW-WM). Global cognitive performance was assessed using the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating-Sum of Boxes (CDR-SB). Mediation analyses examined indirect effects, and longitudinal cognitive outcomes were analyzed using linear mixed-effects and Cox proportional hazards models.Results\n\nAmong 346 participants, 87 (25.1%) had at least one stenotic cerebral artery. Stenosis burden was associated with a lower DTI-ALPS index (β = -0.04, p = 0.003) and higher FW-WM (β = 0.01, p = 0.022). Both DTI-ALPS and FW-WM significantly mediated the association between stenosis burden and baseline MMSE, accounting for 13.06%-17.19% of the total effect. In longitudinal analyses, participants with stenosis and impaired glymphatic function had a higher risk of CDR-SB worsening relative to those with stenosis but preserved glymphatic function (hazard ratios 1.35-2.96) and those without stenosis (hazard ratios 3.27-4.70).Conclusion\n\nThese findings suggest that glymphatic dysfunction may contribute to the association between cerebral artery stenosis and cognitive deterioration.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.",
    "Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Guangzhou, China.",
    "National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Weizhuang Yuan",
      "orcid": "0000-0002-3152-497X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xingyang Niu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Linfang Lan",
      "orcid": "0000-0003-0044-8350"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xinran Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1040mc3qc8819.bib",
  "cited_by": 0,
  "doi": "10.1002/cns.71216",
  "fulltext_url": "https://europepmc.org/articles/PMC13685670",
  "id": "1040mc3qc8819",
  "issns": [
    "1755-5930",
    "1755-5949"
  ],
  "landing_url": "https://europepmc.org/article/MED/42904869",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Cerebrospinal fluid and hydrocephalus"
    ]
  ],
  "openalex": "W7223104604",
  "pdf_url": "https://europepmc.org/articles/PMC13685670?pdf=render",
  "pmcid": "PMC13685670",
  "pmid": "42904869",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1040mc3qc8819.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42904869",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42904869"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Cerebrospinal fluid and hydrocephalus",
      "subfield": "neuroscience"
    }
  ],
  "title": "Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community-Dwelling Older Adults.",
  "title_text": "Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community-Dwelling Older Adults.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/1040mc3qc8819",
  "venue": "CNS neuroscience & therapeutics",
  "versions": []
}