{
  "abstract": "Infectious or biofilm-related inflammatory complications after dermal filler injection are uncommon but may be recurrent and challenging to manage. We report the case of a 44-year-old woman with recurrent erythema, tenderness, and induration in the right tear trough/infraorbital region after facial filler injection performed at an outside facility (reportedly hyaluronic acid, but the filler type was unverified). She had a normal temperature and normal routine laboratory test results. Because ultrasound suggested a small, immature fluid collection and the patient preferred conservative treatment, no incision and drainage was performed. She was treated with repeated intralesional injections of 5-fluorouracil, triamcinolone acetonide, and hyaluronidase. After multiple relapses despite prior systemic antibiotic therapy (details unavailable), repeated intralesional combination therapy achieved sustained clinical resolution. A localized contour depression was noted during follow-up. Intralesional 5-fluorouracil with triamcinolone and hyaluronidase may be a salvage option for refractory postfiller inflammatory complications with suspected infectious/biofilm involvement, particularly when conventional approaches are unsuccessful. Further studies are needed to define indications and optimal dosing.",
  "abstract_shown": true,
  "affiliations": [
    "From the Department of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
    "Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mengzhe Qin"
    },
    {
      "affs": [
        0
      ],
      "name": "Yutong Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaqi Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueshang Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Jun Zhuang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ziming Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jintian Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/10bwkx4186s69.bib",
  "cited_by": 0,
  "doi": "10.1097/gox.0000000000008194",
  "fulltext_url": "https://europepmc.org/articles/PMC13680900",
  "id": "10bwkx4186s69",
  "issns": [
    "2169-7574"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903471",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Facial Rejuvenation and Surgery Techniques"
    ]
  ],
  "openalex": "W7223066051",
  "pdf_url": "https://europepmc.org/articles/PMC13680900?pdf=render",
  "pmcid": "PMC13680900",
  "pmid": "42903471",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/10bwkx4186s69.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903471",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903471"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2746|Reconstructive Surgery and Microvascular Techniques",
      "subfield": "surgery"
    }
  ],
  "title": "Recurrent Delayed Inflammatory Reaction After Dermal Filler Injection Treated With Intralesional 5-fluorouracil, Triamcinolone, and Hyaluronidase.",
  "title_text": "Recurrent Delayed Inflammatory Reaction After Dermal Filler Injection Treated With Intralesional 5-fluorouracil, Triamcinolone, and Hyaluronidase.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/10bwkx4186s69",
  "venue": "Plastic and reconstructive surgery. Global open",
  "versions": []
}