{
  "abstract": "Background\n\nxCT/SLC7A11, an amino acid transporter, is implicated in various cancers. However, its role in rectal cancer remains unclear. This study aimed to explore its predictive value for prognosis and chemoradiotherapy response in rectal cancer patients.Methods and materials\n\nxCT expression was assessed using immunohistochemistry and RT-qPCR, and its associations with clinicopathological features and prognosis were analyzed. Single-cell RNA sequencing data and the TIMER platform were used to examine xCT's correlation with immune cell infiltration. A prognostic nomogram model was developed and evaluated with ROC, calibration, and decision curve analysis. Cell proliferation and cytotoxicity assays were conducted to assess xCT's role in ferroptosis and chemoradiotherapy sensitivity.Results\n\nxCT expression was elevated in rectal cancer tissues and correlated with adverse clinicopathological features, including tumor regression grade (P < 0.001). Single-cell and immune infiltration analyses indicated that xCT was associated with the immune microenvironment. High xCT expression predicted worse overall and disease-free survival, and multivariate analysis confirmed it as an independent prognostic factor. The xCT-based nomogram accurately predicted 1- and 3-year survival rates. Additionally, xCT knockout inhibited cell proliferation and enhanced chemoradiotherapy sensitivity in vitro and in vivo by promoting ferroptosis.Conclusion\n\nHigh expression of xCT was associated with poor prognosis and chemoradiotherapy response in rectal cancer, representing a potential prognostic marker and therapeutic target.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, Hernia and Abdominal Wall Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, P.R. China.",
    "Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, P.R. China.",
    "Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, P.R. China.",
    "Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Qingyuan People's Hospital, Guangzhou Medical University, Qing yuan, 511518, Guangdong, P.R. China.",
    "Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Qingyuan People's Hospital, Guangzhou Medical University, Qing yuan, 511518, Guangdong, P.R. China. thoes007@126.com.",
    "Department of General Surgery, Hernia and Abdominal Wall Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, P.R. China. zengbing3@mail.sysu.edu.cn.",
    "Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, P.R. China. zengbing3@mail.sysu.edu.cn.",
    "Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, P.R. China. zengbing3@mail.sysu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yingru Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Heng LiuFu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zhilong Yuan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wenchang Gan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shaoyong Peng"
    },
    {
      "affs": [
        3
      ],
      "name": "Jinhong Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Haiyang Xin"
    },
    {
      "affs": [
        4
      ],
      "name": "Canfeng Cai"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Bing Zeng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/10wngzmfb675e.bib",
  "cited_by": 0,
  "doi": "10.1186/s12935-026-04428-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13685374",
  "id": "10wngzmfb675e",
  "issns": [
    "1475-2867"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902388",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH573-671"
    ],
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2740|Ferroptosis and cancer prognosis"
    ]
  ],
  "openalex": "W7171033944",
  "pdf_url": "https://europepmc.org/articles/PMC13685374?pdf=render",
  "pmcid": "PMC13685374",
  "pmid": "42902388",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/10wngzmfb675e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42902388",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902388"
    },
    {
      "first_seen": "2026-10-30T13:46:26Z",
      "native_id": "d050f8d57c0741a08239f7843bce4230",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12935-026-04428-7"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QH573-671",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "High xCT expression indicates poor prognosis and chemoradiotherapy resistance in rectal cancer patients.",
  "title_text": "High xCT expression indicates poor prognosis and chemoradiotherapy resistance in rectal cancer patients.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:26Z",
  "url": "https://research.draconitic.com/paper/10wngzmfb675e",
  "venue": "Cancer cell international",
  "versions": []
}