{
  "abstract": "Periodontitis is a chronic inflammatory disease in which clinical and radiographic assessments reflect the consequences of tissue destruction rather than ongoing biological activity. Salivary Extracellular Vesicles (EVs) have emerged as a promising source of minimally invasive biomarkers capable of reflecting real-time periodontal biology, owing to their stable, membrane-protected cargo of proteins, lipids, and regulatory nucleic acids. Current studies suggest that EVs-associated microRNAs and proteins may help distinguish periodontal health from disease and may reflect biological changes following periodontal therapy. This mini review discusses the biological origin and cargo of salivary EVs and examines their emerging relevance to precision periodontology. EVs derived from mesenchymal and periodontal ligament stem cells also show immunomodulatory, osteogenic, and regenerative effects in experimental models. Although diagnostic and therapeutic evidence is still emerging, growing findings support the potential of EVs-based approaches in periodontology. Further progress through standardised EVs isolation and characterisation, robust biomarker validation, and well-designed clinical studies will facilitate their translation into personalised periodontal care.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Periodontology, AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Nitte (Deemed to be University), Mangalore, India."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amanchi Vineela"
    },
    {
      "affs": [
        0
      ],
      "name": "Amita Rao"
    },
    {
      "affs": [
        0
      ],
      "name": "Srilakshmi Mahadevan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/114ja3we47ezq.bib",
  "cited_by": 0,
  "doi": "10.3389/fdmed.2026.1964471",
  "fulltext_url": "https://europepmc.org/articles/PMC13711376",
  "id": "114ja3we47ezq",
  "issns": [
    "2673-4915"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948552",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Mini Review"
    ],
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7221692460",
  "pdf_url": "https://europepmc.org/articles/PMC13711376?pdf=render",
  "pmcid": "PMC13711376",
  "pmid": "42948552",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/114ja3we47ezq.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42948552",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948552"
    },
    {
      "first_seen": "2026-10-31T12:22:10Z",
      "native_id": "PMC13711376",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fdmed.2026.1964471"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Extracellular vesicles in disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Salivary extracellular vesicles in precision periodontology: diagnostic biomarkers and therapeutic opportunities.",
  "title_text": "Salivary extracellular vesicles in precision periodontology: diagnostic biomarkers and therapeutic opportunities.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:10Z",
  "url": "https://research.draconitic.com/paper/114ja3we47ezq",
  "venue": "Frontiers in dental medicine",
  "versions": []
}