{
  "abstract": "Prescription and claims data indicate that hydroxyurea (HU) adherence is low among youth with sickle cell disease (SCD). Electronic monitors (EM) are a gold standard measure, yet existing models have significant drawbacks that limit their use in youth with SCD. We developed a small, cellular-connected EM that is compatible with both liquid and capsule HU formulation bottles. In testing this EM among a sample of adolescents and young adults and caregivers of young children with SCD, we found that the EM is feasible and acceptable among youth with SCD and caregivers of young children with SCD in the short-term. We also found that the EM are useful for determining HU adherence and gained user insights that may improve their use longer-term. Future studies should examine the EM ability to determine which youth with SCD could most benefit from HU adherence intervention and treatment escalation in those with optimized adherence.",
  "abstract_shown": true,
  "affiliations": [
    "Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, United States of America.",
    "Hasbro Children's Hospital, Pediatric Hematology/Oncology, Lifespan Comprehensive Sickle Cell Center, Providence, Rhode Island, United States of America.",
    "Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Hematology, Oncology, and Stem Cell Transplant, Chicago, Illinois, United States of America.",
    "Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.",
    "Scene Health, Brooklandville, Maryland, United States of America.",
    "Brown University Health, Pediatric Hematology and Oncology, Providence, Rhode Island, United States of America.",
    "Department of Hematology, Oncology, and Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio, United States of America."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anyssa Young",
      "orcid": "0009-0003-5935-6829"
    },
    {
      "affs": [
        0
      ],
      "name": "Nate Goldfarb"
    },
    {
      "affs": [
        1
      ],
      "name": "Patrick McGann"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Sherif M Badawy"
    },
    {
      "affs": [
        4
      ],
      "name": "Sebastian Seiguer"
    },
    {
      "affs": [
        2
      ],
      "name": "Savannah Winkler"
    },
    {
      "affs": [
        2
      ],
      "name": "Erika Huerta"
    },
    {
      "affs": [
        5
      ],
      "name": "Lisbel Gonzalez"
    },
    {
      "affs": [
        4
      ],
      "name": "Saige Armistead"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Susan Creary",
      "orcid": "0000-0002-4730-8139"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/119q4wzrh304a.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0358450",
  "fulltext_url": "https://europepmc.org/articles/PMC13686269",
  "id": "119q4wzrh304a",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0358450",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2714|Medication Adherence and Compliance"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical genetics/Genetic diseases/Autosomal recessive diseases/Sickle cell disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Clinical trials/Randomized controlled trials"
    ],
    [
      "plos",
      "/Medicine and health sciences/Health care/Caregivers"
    ],
    [
      "plos",
      "/Medicine and health sciences/Hematology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Hematology/Hemoglobinopathies/Sickle cell disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Genetic diseases/Autosomal recessive diseases/Sickle cell disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pediatrics"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmaceutics/Pharmaceutical processing technology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmacology/Drug research and development/Clinical trials/Randomized controlled trials"
    ],
    [
      "plos",
      "/People and places/Population groupings/Age groups/Adults/Young adults"
    ],
    [
      "plos",
      "/Research and analysis methods/Clinical trials/Randomized controlled trials"
    ],
    [
      "plos",
      "/Research and analysis methods/Research design/Survey research/Surveys"
    ]
  ],
  "openalex": "W7223082839",
  "pdf_url": "https://europepmc.org/articles/PMC13686269?pdf=render",
  "pmcid": "PMC13686269",
  "pmid": "42905657",
  "published": "2026-10-21",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/119q4wzrh304a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:23Z",
      "native_id": "10.1371/journal.pone.0358450",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0358450"
    },
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42905657",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905657"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:clinical trials",
      "subfield": "clinical-trials"
    }
  ],
  "title": "A liquid- and capsule-compatible hydroxyurea electronic monitor to identify non-adherent youth with sickle cell disease",
  "title_text": "A liquid- and capsule-compatible hydroxyurea electronic monitor to identify non-adherent youth with sickle cell disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/119q4wzrh304a",
  "venue": "PLOS One",
  "versions": []
}