{
  "abstract": "BACKGROUND: Pediatric asthma is a heterogeneous disease with distinct inflammatory phenotypes. Asthma with blood eosinophilia (driven by type 2 inflammation) is associated with increased asthma severity and poor asthma control. However, pediatric data including that from resource-limited settings [low-and-middle-income country (LMIC)] remains limited.\n\nAIM: To evaluate the clinical characteristics, asthma severity, and lung function in children with asthma and blood eosinophilia from a LMIC setting.\n\nMETHODS: This retrospective cohort study included children aged 5-14 years with asthma evaluated at a tertiary care center in Eastern India between March 1, 2017 and February 29, 2020. Blood eosinophilia was defined as an absolute eosinophil count (AEC) of ≥ 400 cells/mm3. The primary outcome was the association between blood eosinophilia and asthma control. Secondary outcomes included asthma severity, spirometry parameters, serum immunoglobulin E (IgE) levels, and factors independently associated with eosinophilia. Clinical characteristics, asthma control test scores, lung function parameters, and serum IgE levels were compared between children with and without eosinophilia. Multivariate analysis was performed to identify factors independently associated with blood eosinophilia.\n\nRESULTS: Among 176 children included in the analysis, 84 (47.8%) had blood eosinophilia. Poor asthma control was more common in children with eosinophilia than in those without eosinophilia (51.2% vs 34.8%, P = 0.027). Eosinophilia was significantly associated with moderate and severe asthma and with greater airway obstruction, reflected by a lower mean forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio (65.5% vs 69.7%, P = 0.006). Median serum IgE levels were significantly increased in the eosinophilic group (295 vs 98 kIU/L, P < 0.001). On multivariate analysis, age > 8 years, elevated serum IgE (> 300 kIU/L), poor asthma control, and reduced FEV1/FVC ratio were independently associated with blood eosinophilia.\n\nCONCLUSION: Childhood asthma with blood eosinophilia (an AEC of ≥ 400 cells/mm3) is associated with poor control, greater disease severity, and increased airflow limitation. Peripheral eosinophil count may serve as an important biomarker for risk stratification and personalized asthma management in a LMIC setting.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Rashmi Ranjan Das"
    },
    {
      "name": "Manoj Kumar Panigrahi"
    },
    {
      "name": "Samarendra Mahapatro"
    },
    {
      "name": "Joseph John"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/119w79smw941f.bib",
  "cited_by": 0,
  "doi": "10.5409/wjcp.122880",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720631/",
  "id": "119w79smw941f",
  "issns": [
    "2219-2808"
  ],
  "landing_url": "https://doi.org/10.5409/wjcp.122880",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Retrospective Cohort Study"
    ],
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7166069199",
  "pdf_url": "https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=122880&filepath=8E31D0401EB18CD6271A9142AB7E05E34CFFCA3613D2D7A6AAD37F5C292F06CA758D8292005020C0",
  "pmcid": "PMC13720631",
  "pmid": "42964450",
  "published": "2026-11-03",
  "publisher": "Baishideng Publishing Group Inc",
  "ris": "https://research.draconitic.com/paper/119w79smw941f.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:28Z",
      "native_id": "PMC13720631",
      "source": "pmc",
      "url": "https://doi.org/10.5409/wjcp.122880"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "Clinical and functional correlates of blood eosinophilia in pediatric asthma: A retrospective cohort study",
  "title_text": "Clinical and functional correlates of blood eosinophilia in pediatric asthma: A retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:28Z",
  "url": "https://research.draconitic.com/paper/119w79smw941f",
  "venue": "World Journal of Clinical Pediatrics",
  "versions": []
}