{
  "abstract": "Background: Cervical cancer is the leading cause of cancer mortality among women in Uganda. This study evaluated screening positivity, diagnostic performance, and treatment cascade outcomes across three districts (2024–2025).\n\nMethods: Retrospective analysis of 24,660 records from the Cervical Cancer Screening and Pre-Cancer Treatment Register (Kampala, Mbarara City, Mbarara District). Modalities included VIA, HPV DNA testing, and Pap smear. Analyses were stratified by district, age, and HIV status.\n\nResults: Of 24,660 women enrolled, 44.9% were from Kampala, 31.6% Mbarara City, and 20.7% Mbarara District. Among initial screeners (n = 14,665), positivity was 12.9%; overall positivity across 23,435 screened women was 13.9% (3,252/23,435). Positivity varied by district (Kampala 14.8%, Mbarara City 11.2%, Mbarara District 11.6%), rose with age (6.5% under 25 to 17.6% aged 50+), and was higher among HIV-positive women (23.1% vs. 10.3%). HPV DNA testing had higher positivity than VIA or Pap smear (25.0% vs. 11.0%); 74.3% of HPV-positive women were also VIA-positive. Invasive cancer was found in 4.3% of screen-positive women (140/3,252), rising to 20.9% in those aged 50+. HIV-positive women accounted for 42 of 140 invasive cases. Approximately 30% of screen-positive women were untreated overall; the gap was highest among first-time screeners (∼40%).\n\nConclusions: A critical treatment gap persists. Women living with HIV, women aged 40+, and first-time screeners require targeted interventions to improve linkage to treatment and reduce cervical cancer mortality in Uganda.\n\nKey messages: • Despite scale-up, 30% of screen-positive women in Uganda were not treated, rising to 40% among first-time screeners — revealing a critical gap between screening and care.\n\n• HIV-positive women and those aged 50+ bear the highest cervical cancer burden. Targeted interventions are urgently needed to close the treatment gap and save lives in Uganda.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "abstract",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "J Akamumpa"
    },
    {
      "name": "K Moran"
    },
    {
      "name": "B Dahye"
    },
    {
      "name": "C Mpaamani"
    },
    {
      "name": "M Origa"
    },
    {
      "name": "N N Niyonzima"
    },
    {
      "name": "A N Namuli"
    },
    {
      "name": "F M Mugabe"
    },
    {
      "name": "N E Nankya"
    },
    {
      "name": "J Orem"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/11cs0tnqfezzq.bib",
  "cited_by": 0,
  "doi": "10.1093/eurpub/ckag169.1108",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13699553/",
  "id": "11cs0tnqfezzq",
  "issns": [
    "1101-1262",
    "1464-360X"
  ],
  "landing_url": "https://doi.org/10.1093/eurpub/ckag169.1108",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "6. Poster Displays"
    ],
    [
      "heading",
      "AcademicSubjects/MED00860"
    ],
    [
      "heading",
      "AcademicSubjects/SOC01210"
    ],
    [
      "heading",
      "AcademicSubjects/SOC02610"
    ],
    [
      "heading",
      "DB. Chronic diseases, multimorbidity and non-communicable diseases"
    ],
    [
      "openalex",
      "2713|Cervical Cancer and HPV Research"
    ]
  ],
  "openalex": "W7223660144",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13699553/pdf/?tool=EBI",
  "pmcid": "PMC13699553",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/11cs0tnqfezzq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:09Z",
      "native_id": "PMC13699553",
      "source": "pmc",
      "url": "https://doi.org/10.1093/eurpub/ckag169.1108"
    },
    {
      "first_seen": "2026-10-30T12:21:45Z",
      "native_id": "PMC:PMC13699553",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13699553"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Cervical Cancer and HPV Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Cervical Cancer Screening Cascade Performance Across Three Regional Districts in Uganda, 2024–2025",
  "title_text": "Cervical Cancer Screening Cascade Performance Across Three Regional Districts in Uganda, 2024–2025",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:36:07Z",
  "url": "https://research.draconitic.com/paper/11cs0tnqfezzq",
  "venue": "The European Journal of Public Health",
  "versions": []
}