{
  "abstract": "Introduction\n\nFibrosis-4 (FIB-4) and fibrosis-5 (FIB-5) indices are non-invasive biomarkers originally developed for hepatic fibrosis but may reflect systemic pathophysiological changes related to adverse cardiovascular prognosis. We aimed to investigate whether baseline FIB-4 and FIB-5 values predict long-term mortality in patients with heart failure (HF).Methods\n\nThis retrospective observational study included 593 patients with HF who had available long-term mortality data. FIB-4 and FIB-5 indices were calculated at admission. Patients were followed for all-cause mortality, and outcomes were evaluated at 1-year, 3-year, and 5-year intervals. Clinical, laboratory, and echocardiographic parameters were compared between survivors and non-survivors.Results\n\nDuring follow-up, 1-year, 3-year, and 5-year mortality rates were 24.6%, 39.0%, and 49.7%, respectively. Non-survivors had significantly higher FIB-4 and FIB-5 values compared with survivors (P<0.001 for both). ROC curve analyses demonstrated that both indices had significant predictive performance for long-term mortality. Optimal cut-off values showed good sensitivity and specificity for identifying high-risk patients.Conclusion\n\nHigher FIB-4 and FIB-5 values are associated with greater long-term mortality risk in HF patients. These indices may serve as practical, cost-effective prognostic biomarkers for mortality risk stratification in routine clinical care.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Eskişehir City Hospital, Eskişehir, Turkey.",
    "Department of Cardiology, Muş State Hospital, Muş, Turkey.",
    "Department of Cardiology, Eskişehir Osmangazi University Hospital, Eskişehir, Turkey."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Halit Emre Yalvaç",
      "orcid": "0000-0003-2620-9948"
    },
    {
      "affs": [
        1
      ],
      "name": "Fatih Enes Durmaz",
      "orcid": "0000-0002-9688-110X"
    },
    {
      "affs": [
        0
      ],
      "name": "Bektaş Murat",
      "orcid": "0000-0002-6564-7185"
    },
    {
      "affs": [
        2
      ],
      "name": "Selda Murat",
      "orcid": "0000-0002-3935-0222"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/11dh7f0yss7yf.bib",
  "cited_by": 0,
  "doi": "10.34172/jcvtr.33476",
  "fulltext_url": "https://europepmc.org/articles/PMC13677615",
  "id": "11dh7f0yss7yf",
  "issns": [
    "2008-5117",
    "2008-6830"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898407",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7219675740",
  "pdf_url": "https://europepmc.org/articles/PMC13677615?pdf=render",
  "pmcid": "PMC13677615",
  "pmid": "42898407",
  "published": "2026-06-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/11dh7f0yss7yf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42898407",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898407"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Association of Value of Fibrosis-4 Index with Long-Term Mortality in Patients with Heart Failure: A Comparison Study with Fibrosis-5 Index.",
  "title_text": "Association of Value of Fibrosis-4 Index with Long-Term Mortality in Patients with Heart Failure: A Comparison Study with Fibrosis-5 Index.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:42Z",
  "url": "https://research.draconitic.com/paper/11dh7f0yss7yf",
  "venue": "Journal of cardiovascular and thoracic research",
  "versions": []
}