{
  "abstract": "We present a compartmentalized microfluidic trichannel model of the gut-brain axis that reveals how microbial metabolites communicate with neurons. Using this model, we show that butyrate triggers colonic serotonin release, which activates neuronal signaling through calcium influx. This work highlights the power of microfluidic models to uncover mechanisms of gut-brain communication in a controlled, in vitro setting.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, Ohio, USA",
    "Department of Neurosciences, The University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA",
    "Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL, USA",
    "Department of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida Tampa, FL, USA",
    "Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Awurama Ofori-Kwafo"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Hemaa Sree Kumar"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Emily B. Otmanowski"
    },
    {
      "affs": [
        0
      ],
      "name": "Earshed Al Mamun"
    },
    {
      "affs": [
        3
      ],
      "name": "Ajla Habibic-Beskovic"
    },
    {
      "affs": [
        4
      ],
      "name": "Qiuhong Li"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Jasenka Zubcevic"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/11hqby8vqh253.bib",
  "cited_by": 0,
  "doi": "10.1152/ajpgi.00014.2026",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724143/",
  "id": "11hqby8vqh253",
  "issns": [
    "0193-1857",
    "1522-1547"
  ],
  "landing_url": "https://doi.org/10.1152/ajpgi.00014.2026",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
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  "openalex": "W7214965089",
  "pdf_url": null,
  "pmcid": "PMC13724143",
  "pmid": "42814738",
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/11hqby8vqh253.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:39Z",
      "native_id": "PMC13724143",
      "source": "pmc",
      "url": "https://doi.org/10.1152/ajpgi.00014.2026"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Butyrate Triggers Neuronal Signaling via Release of Colonic Serotonin in a Microfluidic Model of Gut-Brain Axis",
  "title_text": "Butyrate Triggers Neuronal Signaling via Release of Colonic Serotonin in a Microfluidic Model of Gut-Brain Axis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:50Z",
  "url": "https://research.draconitic.com/paper/11hqby8vqh253",
  "venue": "American journal of physiology. Gastrointestinal and liver physiology",
  "versions": []
}