{
  "abstract": "Background Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare, treatable inflammatory variant of cerebral amyloid angiopathy characterized by heterogeneous clinical manifestations and ambiguous imaging features, frequently leading to delayed diagnosis. Case Description This report describes a 70-year-old hypertensive male who presented with subacute progressive cognitive decline, severe headache, vomiting, and blurred vision. Neurological examination revealed left homonymous hemianopia and mild cognitive impairment (MMSE 21/30). Brain non-contrast MRI demonstrated extensive asymmetric T2/FLAIR white matter hyperintensities with mild mass effect, multiple strictly lobar microbleeds on susceptibility-weighted imaging (SWI), and patchy subcortical DWI-positive ischemic lesions with corresponding ADC changes without appreciable parenchymal or meningeal enhancement. Lumbar puncture revealed isolated mild elevation of cerebrospinal fluid (CSF) protein (0.8 g/L) without pleocytosis. ApoE genotyping confirmed an ε4/ε4 homozygous genotype. The patient was recommended corticosteroid therapy but declined and transferred to another institution, where he received methylprednisolone . His symptoms resolved dramatically , and the two-year follow-up MRI showed significant resolution of the previously extensive white matter lesions , with only mild residual Fazekas grade 2 leukoaraiosis. Conclusion This case fulfills the validated Auriel clinicoradiological criteria for probable CAA-RI without pathological confirmation. ApoE ε4/ε4 genotyping may provide supportive auxiliary evidence rather than a definitive diagnostic index. Combined interpretation of clinical symptoms, characteristic multimodal MRI findings, and genetic susceptibility evidence can substantially improve the diagnostic accuracy of probable CAA-RI in clinical practice.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Tianheng Zheng"
    },
    {
      "name": "Kangqing Zhang"
    },
    {
      "name": "Junjie Hao"
    },
    {
      "name": "Yibin Fang"
    },
    {
      "name": "Huazheng Liang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/11m9s6vvpafkw.bib",
  "cited_by": 0,
  "doi": "10.1177/11795735261502255",
  "fulltext_url": "https://doi.org/10.1177/11795735261502255",
  "id": "11m9s6vvpafkw",
  "issns": [
    "1179-5735"
  ],
  "landing_url": "https://doi.org/10.1177/11795735261502255",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC346-429"
    ],
    [
      "openalex",
      "2728|Intracerebral and Subarachnoid Hemorrhage Research"
    ]
  ],
  "openalex": "W7224438893",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "SAGE Publishing",
  "ris": "https://research.draconitic.com/paper/11m9s6vvpafkw.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:34Z",
      "native_id": "006d2d20fe1e49a491a492eefeed3405",
      "source": "doaj",
      "url": "https://doi.org/10.1177/11795735261502255"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracerebral and Subarachnoid Hemorrhage Research",
      "subfield": "neurology"
    }
  ],
  "title": "Probable Cerebral Amyloid Angiopathy-Related Inflammation: A Case Report",
  "title_text": "Probable Cerebral Amyloid Angiopathy-Related Inflammation: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:34Z",
  "url": "https://research.draconitic.com/paper/11m9s6vvpafkw",
  "venue": "Journal of Central Nervous System Disease",
  "versions": []
}