{
  "abstract": "Coordinated cortical activity underlies voluntary movement planning, yet its disruption is implicated in neurodevelopmental disorders like autism spectrum disorder (ASD). Mutations in the SHANK3 gene, a key ASD risk factor, affect synaptic integrity and cortical network function, but their impact on preparatory cortical dynamics remains unclear. Here, we employed wide-field calcium imaging combined with motion tracking and computational motif analysis to examine cortex-wide activity in Shank3b + /- mice during spontaneous forepaw movements. We found reduced correlation between cortical activity and behavior preceding movement onset, alongside decreased expression of specific cortical motifs involving associative and motor areas. These changes contributed to global functional hyperconnectivity and impaired motor planning. Our findings reveal that disrupted spatiotemporal cortical dynamics in Shank3b + /- mice impair preparatory motor processes, providing insight into neural mechanisms underlying ASD-related motor deficits.",
  "abstract_shown": true,
  "affiliations": [
    "European Laboratory for Non-Linear Spectroscopy, Florence, Italy",
    "National Research Council, Neuroscience Institute, Pisa, Italy",
    "Physics and Astronomy Department, University of Florence, Sesto Fiorentino, Italy",
    "Princeton Neuroscience Institute, Princeton University, Washington Rd, Princeton, NJ USA",
    "Department of Psychology, Princeton University, Washington Rd, Princeton, NJ USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Manuel Ambrosone",
      "orcid": "0009-0001-3714-2729"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elena Montagni",
      "orcid": "0000-0003-1106-7115"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Timothy J. Buschman",
      "orcid": "0000-0003-1298-2761"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Anna Letizia Allegra Mascaro",
      "orcid": "0000-0002-8489-0076"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/12j8e98q56kz1.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-10660-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737098/",
  "id": "12j8e98q56kz1",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://doi.org/10.1038/s42003-026-10660-8",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1311|Genetics and Neurodevelopmental Disorders"
    ]
  ],
  "openalex": "W7168125970",
  "pdf_url": "https://www.nature.com/articles/s42003-026-10660-8_reference.pdf",
  "pmcid": "PMC13737098",
  "pmid": "42443502",
  "published": "2026-07-13",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/12j8e98q56kz1.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:23Z",
      "native_id": "PMC13737098",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s42003-026-10660-8"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetics and Neurodevelopmental Disorders",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice",
  "title_text": "Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:23Z",
  "url": "https://research.draconitic.com/paper/12j8e98q56kz1",
  "venue": "Communications Biology",
  "versions": []
}